Germline variation networks in the PI3K/AKT pathway corresponding to familial high-incidence lung cancer pedigrees

Table 1 Odds ratios for risk of lung cancer among first-degree relatives

Factors	Case/Control	Crude OR (95%CI)	Adjusted OR^a (95%CI)	P-value
Family history of any cancer
No	432/438	1.00	1.00
Yes	201/127	1.60(1.24,2.08)	1.71(1.28,2.28)	< 0.001
Family history of lung cancer
No	560/534	1.00	1.00
Yes	73/31	2.25(1.45,3.47)	2.20(1.36,3.55)	< 0.001
N of pedigrees with
0	432//438	1.00	1.00
1	149/111	1.36(1.03,1.80)	1.55(1.14,2.12)	0.002
≥ 2 any cancers	52/16	3.30(1.85,5.86)	2.65(1.42,4.94)	0.001
N of pedigrees with
0	560/534	1.00	1.00
1	65/30	2.07(1.32, 3.24)	2.11(1.29, 3.44)	0.001
≥ 2 lung cancers	8/1	7.63(0.95, 61.20)	4.49(0.51, 39.27)	0.029

^a Adjusted for sex, smoking index, lung disease history, living environment, and occupational exposure

ISSN: 1471-2407