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Table 2 Multivariate Cox regression analysis of local control and overall survival

From: Analyses of the local control of pulmonary Oligometastases after stereotactic body radiotherapy and the impact of local control on survival

Factors

Covariate

Local control

Overall survival

HR (95% CI)

P value

HR (95% CI)

P value

Local status

Controlled

–

–

reference

 
 

Failed

–

–

2.390 (1.839–3.106)

< 0.001

ECOG PS

0

–

–

reference

 
 

1

–

–

1.316 (1.059–1.635)

0.013

 

2–3

–

–

2.008 (1.405–2.869)

< 0.001

Primary lesion sites

Colorectum

reference

 

reference

 
 

Lung

0.413 (0.274–0.622)

< 0.001

0.936 (0.685–1.280)

0.681

 

H&N

0.194 (0.077–0.489)

< 0.001

0.905 (0.556–1.474)

0.690

 

Oesophagus

0.618 (0.306–1.248)

0.179

1.650 (1.027–2.650)

0.038

 

Others

0.337 (0.208–0.546)

< 0.001

1.208 (0.863–1.691)

0.270

Pathology of primary lesion

Adenoca.

–

–

reference

 

SqCC

–

–

1.525 (1.122–2.072)

0.006

 

Others

–

–

1.291 (0.916–1.818)

0.143

Oligometastatic state

Oligo-rec

–

–

reference

 
 

Sync-oligo

–

–

1.391 (0.988–1.960)

0.058

 

Unclassified

–

–

1.246 (0.905–1.714)

0.177

Chemotherapy concurrent with SBRT

Yes

1.969 (0.859–4.513)

0.109

–

–

No

reference

 

–

–

Maximum tumour diameter

Per 1 cm

1.297 (1.059–1.588)

0.011

1.266 (1.131–1.417)

< 0.001

Dose calculation algorithm

Type A

reference

 

–

–

 

Type B

0.592 (0.410–0.856)

0.005

–

–

 

Type C

0.732 (0.371–1.445)

0.368

–

–

BED10 at isocenter

Per 10 Gy

0.912 (0.828–1.006)

0.065

–

–

OTT of SBRT

Per 10 days

0.610 (0.385–0.966)

0.035

–

–

  1. Abbreviations: HR Hazard ratio, CI Confidence interval, ECOG Eastern Cooperative Oncology Group, PS Performance status, H&N Head and neck, Adenoca. Adenocarcinoma, SqCC Squamous cell carcinoma, Oligo-rec. Oligo-recurrences, Sync-oligo Sync-oligometastases, SBRT Stereotactic body radiotherapy, BED Biological effective dose, OTT Overall treatment time