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Table 2 Multivariate Cox regression analysis of local control and overall survival

From: Analyses of the local control of pulmonary Oligometastases after stereotactic body radiotherapy and the impact of local control on survival

Factors Covariate Local control Overall survival
HR (95% CI) P value HR (95% CI) P value
Local status Controlled reference  
  Failed 2.390 (1.839–3.106) < 0.001
ECOG PS 0 reference  
  1 1.316 (1.059–1.635) 0.013
  2–3 2.008 (1.405–2.869) < 0.001
Primary lesion sites Colorectum reference   reference  
  Lung 0.413 (0.274–0.622) < 0.001 0.936 (0.685–1.280) 0.681
  H&N 0.194 (0.077–0.489) < 0.001 0.905 (0.556–1.474) 0.690
  Oesophagus 0.618 (0.306–1.248) 0.179 1.650 (1.027–2.650) 0.038
  Others 0.337 (0.208–0.546) < 0.001 1.208 (0.863–1.691) 0.270
Pathology of primary lesion Adenoca. reference  
SqCC 1.525 (1.122–2.072) 0.006
  Others 1.291 (0.916–1.818) 0.143
Oligometastatic state Oligo-rec reference  
  Sync-oligo 1.391 (0.988–1.960) 0.058
  Unclassified 1.246 (0.905–1.714) 0.177
Chemotherapy concurrent with SBRT Yes 1.969 (0.859–4.513) 0.109
No reference  
Maximum tumour diameter Per 1 cm 1.297 (1.059–1.588) 0.011 1.266 (1.131–1.417) < 0.001
Dose calculation algorithm Type A reference  
  Type B 0.592 (0.410–0.856) 0.005
  Type C 0.732 (0.371–1.445) 0.368
BED10 at isocenter Per 10 Gy 0.912 (0.828–1.006) 0.065
OTT of SBRT Per 10 days 0.610 (0.385–0.966) 0.035
  1. Abbreviations: HR Hazard ratio, CI Confidence interval, ECOG Eastern Cooperative Oncology Group, PS Performance status, H&N Head and neck, Adenoca. Adenocarcinoma, SqCC Squamous cell carcinoma, Oligo-rec. Oligo-recurrences, Sync-oligo Sync-oligometastases, SBRT Stereotactic body radiotherapy, BED Biological effective dose, OTT Overall treatment time