Table 3 Predictors of subsequent treatment for non-transplant and transplant patients with NDMM

Age at MM diagnosis, years

 < 65

0.90 (0.84–0.97)

0.0035

1.01 (0.92–1.11)

0.7975

1.09 (0.98–1.22)

0.1154

1.08 (0.94–1.25)

0.2889

 65–74

Reference

Reference

Reference

Reference

 75–84

0.86 (0.80–0.91)

< 0.0001

0.84 (0.77–0.90)

< 0.0001

0.86 (0.78–0.94)

0.0010

0.91 (0.80–1.03)

0.1173

 ≥ 85

0.47 (0.42–0.53)

< 0.0001

0.45 (0.40–0.52)

< 0.0001

0.44 (0.38–0.52)

< 0.0001

0.55 (0.44–0.69)

< 0.0001

Sex, male

0.96 (0.91–1.01)

0.1494

1.03 (0.96–1.10)

0.3843

1.08 (1.00–1.17)

0.0509

1.10 (0.99–1.22)

0.0871

Comorbidities during 180 days prior to index MM diagnosis

 Cardiovascular disorders^c

0.84 (0.79–0.90)

< 0.0001

0.84 (0.78–0.91)

< 0.0001

0.83 (0.76–0.91)

< 0.0001

0.88 (0.78–1.00)

0.0479

 Liver disease

0.91 (0.80–1.04)

0.1573

0.88 (0.75–1.03)

0.1195

0.88 (0.72–1.06)

0.1784

0.73 (0.57–0.94)

0.0149

 Pulmonary circulation disorders

0.75 (0.66–0.86)

< 0.0001

0.76 (0.64–0.89)

0.0009

0.75 (0.62–0.91)

0.0030

0.79 (0.60–1.04)

0.0924

 Renal impairment

0.91 (0.85–0.98)

0.0112

0.91 (0.83–0.99)

0.0225

0.97 (0.88–1.07)

0.5209

0.94 (0.82–1.07)

0.3363

Transplant patients

Overall (N = 2763)

6+ months follow-up^a (n = 2595)

12+ months follow-up^a (n = 2245)

24+ months follow-up^a (n = 1535)

Predictors of subsequent treatment (receiving LOT2+ vs. only LOT1)

Odds ratio^b (95% CI)

P-value^b

Odds ratio^b (95% CI)

P-value^b

Odds ratio^b (95% CI)

P-value^b

Odds ratio^b (95% CI)

P-value^b

Age at MM diagnosis, years

 < 65

1.05 (0.87–1.27)

0.5989

1.13 (0.92–1.38)

0.2421

1.30 (1.03–1.65)

0.0288

1.40 (1.02–1.91)

0.0380

 65–74

Reference

Reference

Reference

Reference

 75–84

1.21 (0.69–2.12)

0.5059

1.00 (0.57–1.77)

0.9953

1.11 (0.55–2.23)

0.7656

0.75 (0.34–1.67)

0.4855

 ≥ 85

–

–

–

–

–

–

–

–

Sex, male

1.20 (1.00–1.44)

0.0543

1.18 (0.97–1.45)

0.1029

1.18 (0.93–1.49)

0.1650

1.27 (0.94–1.73)

0.1218

Comorbidities during 180 days prior to index MM diagnosis

 Cardiovascular disorders^c

0.85 (0.68–1.08)

0.1790

0.86 (0.67–1.11)

0.2423

0.88 (0.66–1.17)

0.3664

0.99 (0.68–1.45)

0.9528

 Liver disease

0.56 (0.39–0.81)

0.0017

0.49 (0.34–0.70)

0.0001

0.48 (0.31–0.73)

0.0005

0.41 (0.23–0.72)

0.0020

 Pulmonary circulation disorders

0.70 (0.39–1.27)

0.2466

0.60 (0.33–1.09)

0.0926

0.51 (0.26–1.01)

0.0520

0.36 (0.14–0.90)

0.0281

 Renal impairment

0.79 (0.62–1.02)

0.0668

0.71 (0.54–0.92)

0.0099

0.74 (0.55–1.01)

0.0601

0.58 (0.40–0.86)

0.0059