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Table 1 Baseline characteristics

From: Integrated analysis of serum lipid profile for predicting clinical outcomes of patients with malignant biliary tumor

Characteristics n (%)
Total, N 368(100)
Tumor type
 GBC 73 (19.8)
 ICC 74 (20.1)
 ECC 221 (60.0)
Age (years)
 ≤ 60 155 (42.1)
 > 60 213 (57.9)
Sex
 Female 168 (45.7)
 Male 200 (54.3)
BMI at diagnosis, kg/m2
 < 18.5 19 (5.2)
 18.5–22.9 128 (34.8)
 ≥ 23 177 (48.1)
 NA 44 (12.0)
Alcohol
 Yes 90 (24.5)
 No 278 (75.5)
Fatty liver
 Yes 27 (7.3)
 No 341 (92.7)
Jaundice
 Yes 219 (59.5)
 No 149 (40.5)
Tumor size, cm
 D ≤ 2 180 (50.6)
 2 < D ≤ 3 85 (23.1)
 3 < D ≤ 4 35 (9.5)
 D > 4 56 (15.2)
 NA 12 (3.3)
Lymph node metastasis
 Yes 122 (33.2)
 No 246 (66.8)
Extrahepatic involvement
 Yes 252 (68.5)
 No 116 (31.5)
Intrahepatic involvement
 Yes 111 (30.2)
 No 257 (69.8)
Gallbladder involvement
 Yes 91 (24.7)
 No 277 (75.3)
AJCC 8th TNM stage
 I 133 (36.1)
 II 120 (32.6)
 III 115 (31.3)
Tumor differentiation
 Undifferentiation 2 (0.5)
 Low 36 (9.8)
 Low-moderate 98 (26.6)
 Moderate 102 (27.7)
 Moderate-high 28 (7.6)
 High 102 (27.7)
Radical cure
 Yes 232 (63.0)
 No 136 (37.0)
R0
 Yes 248 (67.4)
 No 120 (32.6)
TC level, mmol/L
 ≤ 7.28 301 (81.8)
 > 7.28 67 (18.2)
TG level, mmol/L
 ≤ 3.14 301 (81.8)
 > 3.14 67 (18.2)
HDL level, mmol/L
 ≤ 0.95 205 (55.7)
 >  0.95 163 (44.3)
LDL level, mmol/L
 ≤ 1.96 41 (11.1)
 > 1.96 327 (88.9)
TC/HDL
 ≤ 10.08 256 (69.6)
 >  10.08 112 (30.4)
TG/HDL
 ≤ 4.16 258 (70.1)
 > 4.16 110 (29.9)
ApoA1 level, g/L
 ≤ 1.11 166 (45.1)
 > 1.11 150 (40.8)
 NA 52 (14.1)
ApoB level, g/L
 ≤ 0.90 210 (57.1)
 > 0.90 105 (28.5)
 NA 53 (14.4)
Lipoprotein level, mg/L
 ≤ 72 152 (41.3)
 >  72 118 (32.1)
 NA 98 (26.6)
Albumin level, g/L
 ≤ 35 59 (16.0)
 > 35 305 (82.9)
 NA 4 (1.1)
ALT level, U/L
 ≤ 40 116 (31.5)
 > 40 252 (68.5)
AST level, U/L
 ≤ 40 130 (35.3)
 > 40 233 (63.3)
 NA 5 (1.4)
GGT level, U/L
 ≤ 45 72 (19.5)
 > 45 291 (79.1)
 NA 5 (1.4)
ALP level, U/L
 ≤ 135 121 (32.9)
 > 135 242 (65.7)
 NA 5 (1.4)
LDH level, U/L
 ≤ 250 300 (81.5)
 > 250 61 (16.6)
 NA 7 (1.9)
TBIL level, umol/L
 ≤ 17.1 113 (30.7)
 > 17.1 255 (69.3)
CA199 level, U/mL
 ≤ 37 94 (25.5)
 > 37 263 (71.5)
 NA 11 (3.0)
Overall survival, months 21.9 (11.0–39.0)
  1. ALP Alkaline phosphatase, ALT Alanine aminotransferase, ApoA1 ApolipoproteinA-1, APOB Apolipoprotein B, AST Aspartate aminotransferase, BMI Body mass index, CA199 Carbohydrate antigen 199, CC Cholangiocarcinoma, D maximum diameter of tumor, ECC Extrahepatic cholangiocarcinoma, GBC Gallbladder cancer, GGT Gamma-glutamyl transpeptidase, HDL High-density lipoprotein, ICC Intrahepatic cholangiocarcinoma, LDH Lactate dehydrogenase, LDL low-density lipoprotein, NA Not accessible, R0 Histologically negative surgical margin, TBIL Total bilirubin, TC Total cholesterol, TG Triglycerides