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Table 4 Univariate and multivariate analysis for overall survival (OS)

From: Impact of concomitant systemic treatments on toxicity and intracerebral response after stereotactic radiotherapy for brain metastases

Variables

HR

Univariate analysis

OR

Multivariate analysis

IC95%

p

IC95%

p

Histology (lung vs. others)

1.52

0.97–2.38

0.09

   

Age (> 55 vs. ≤55)

2.05

1.32–3.18

0.004

1.04

1.09–10.7

0.015

Gender (male vs. female)

1.23

0.80–1.88

0.34

   

DS-GPA (> 2.5 vs. ≤2.5)

0.38

0.25–0.58

< 0.001

0.8

0.56–1.28

0.45

RPA (1 vs. > 1)

0.61

0.41–0.93

0.021

0.46

0.21–0.97

0.040

Number of BM (1 vs. > 1)

0.88

0.57–1.36

0.58

   

ECM (yes vs. No)

1.9

1.24–3.10

< 0.001

1.70

0.77–3.75

0.19

KPS (≥80% vs. < 80%)

0.29

0.18–0.49

< 0.001

0.97

0.95–0.99

0.040

GTV volume (< 2.07 vs. ≥2.07)

0.60

0.39–0.93

0.015

0.93

0.85–2.58

0.16

Size (> 10 mm vs. < 10 mm)

1.32

0.83–2.11

0.25

   

Dose distribution (HG vs. INH)

1.32

0.84–2.08

0.21

   

ST concurrently (group 1 vs. group 2)

0.70

0.46–1.07

0.09

   

IT (yes vs. no)

0.55

0.32–0.99

0.08

   

IT concurrently (yes vs. no IT)

0.41

0.23–0.74

0.02

0.22

0.08–0.59

0.003

TT (yes vs. no)

0.79

0.51–1.23

0.32

   

TT concurrently (yes vs. no TKI)

1.01

0.65–1.60

0.95

   

CT (yes vs. no)

1.07

0.70–1.63

0.73

   

CT concurrently (yes vs. no CT)

0.93

0.32–1.41

0.72

   
  1. Abbreviations: DS-GPA Diagnostic-Specific Graded Prognostic Assessment, RPA Recursive partitioning analysis, BM Brain metastases, ECM Extracranial metastases, KPS Karnofsky Performance Status, GTV Gross Tumor Volume, HG Homogeneous, INH Inhomogeneous, ST Systemic Treatment, IT Immunotherapy, TT Targeted therapy, CT Chemotherapy