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Table 1 Critical organs at risk and respective dose constraints

From: Is hypofractionated whole pelvis radiotherapy (WPRT) as well tolerated as conventionally fractionated WPRT in prostate cancer patients? The HOPE trial

 

Arm 1: 45 Gy in 25 fractions

Arm 2: 25 Gy in 5 fractions

Rectum

V29 < 50%

V18 < 50%

V35 ≤ 30%

V20 ≤ 30%

D1 cc ≤ 46 Gy

D1 cc ≤ 26 Gy

Bladder

V29 < 50%

V18 < 50%

V35 ≤ 30%

V20 ≤ 30%

D1 cc ≤ 47 Gy

D1 cc ≤ 26 Gy

Femurs

D10 cc < 45 Gy

D10 cc < 25 Gy

Bowel (including sigmoid)

V45 < 40 cc (acceptable 60 cc)

D1 cc ≤ 47 Gy

V25 < 40 cc (acceptable 60 cc)

D1 cc ≤ 26 Gy

Penile bulb

Mean dose < 35 Gy

Mean dose < 20 Gy