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Table 1 Critical organs at risk and respective dose constraints

From: Is hypofractionated whole pelvis radiotherapy (WPRT) as well tolerated as conventionally fractionated WPRT in prostate cancer patients? The HOPE trial

  Arm 1: 45 Gy in 25 fractions Arm 2: 25 Gy in 5 fractions
Rectum V29 < 50% V18 < 50%
V35 ≤ 30% V20 ≤ 30%
D1 cc ≤ 46 Gy D1 cc ≤ 26 Gy
Bladder V29 < 50% V18 < 50%
V35 ≤ 30% V20 ≤ 30%
D1 cc ≤ 47 Gy D1 cc ≤ 26 Gy
Femurs D10 cc < 45 Gy D10 cc < 25 Gy
Bowel (including sigmoid) V45 < 40 cc (acceptable 60 cc)
D1 cc ≤ 47 Gy
V25 < 40 cc (acceptable 60 cc)
D1 cc ≤ 26 Gy
Penile bulb Mean dose < 35 Gy Mean dose < 20 Gy