Variable | Chemotherapy | Radiation | Surgery | |||
---|---|---|---|---|---|---|
Odds Ratio (95% Confidence Limit) | P value | Odds Ratio (95% Confidence Limit) | P value | Odds Ratio (95% Confidence Limit) | P value | |
Age group | ||||||
  < =60 | Reference |  | Reference |  | Reference |  |
 61–70 | 0.68 (0.62 to 0.75) | < 0.0001 | 0.82 (0.74 to 0.9) | < 0.0001 | 0.57 (0.44 to 0.75) | < 0.0001 |
 71–80 | 0.34 (0.30 to 0.37) | < 0.0001 | 0.61 (0.55 to 0.67) | < 0.0001 | 0.35 (0.27 to 0.46) | < 0.0001 |
  > 80 | 0.09 (0.08 to 0.11) | < 0.0001 | 0.38 (0.34 to 0.43) | < 0.0001 | 0.12 (0.08 to 0.18) | < 0.0001 |
Sex | ||||||
 Female | Reference |  | Reference |  | Reference |  |
 Male | 0.92 (0.85 to 0.99) | 0.0225 | 1.11 (1.04 to 1.18) | 0.0029 | 0.99 (0.82 to 1.21) | 0.9448 |
Year of diagnosis | 1.01 (1 to 1.02) | 0.0337 | 1.00 (0.99 to 1.01) | 0.6327 | 0.99 (0.96 to 1.02) | 0.4833 |
CCI score | ||||||
 0 | Reference |  | Reference |  | Reference |  |
 1 | 0.77 (0.67 to 0.89) | 0.0002 | 1.02 (0.89 to 1.17) | 0.7471 | 0.79 (0.55 to 1.13) | 0.1945 |
  > 1 | 0.68 (0.61 to 0.75) | < 0.0001 | 1.16 (1.04 to 1.29) | 0.0058 | 0.68 (0.52 to 0.9) | 0.0078 |
Cardiovascular disease | ||||||
 No | Reference |  | Reference |  | Reference |  |
 Yes | 0.53 (0.48 to 0.58) | < 0.0001 | 0.76 (0.70 to 0.82) | < 0.0001 | 0.56 (0.44 to 0.7) | < 0.0001 |
Histology | ||||||
 Adenocarcinoma | Reference |  | Reference |  | Reference |  |
 SCC | 0.61 (0.55 to 0.68) | < 0.0001 | 0.77 (0.71 to 0.85) | < 0.0001 | 0.12 (0.08 to 0.16) | < 0.0001 |
 SCLC | 6.64 (5.93 to 7.45) | < 0.0001 | 2.17 (1.96 to 2.39) | < 0.0001 | 0.47 (0.37 to 0.61) | < 0.0001 |
 Carcinoid/LCNE | 1.05 (0.84 to 1.31) | 0.6779 | 0.82 (0.62 to 1.08) | 0.1480 | 3.46 (2.16 to 5.54) | < 0.0001 |
 Large cell ca | 0.79 (0.58 to 1.08) | 0.1382 | 1.98 (1.45 to 2.71) | < 0.0001 | 9.65 (4.74 to 19.6) | < 0.0001 |
 Others | 6.64 (5.93 to 7.45) | < 0.0001 | 0.71 (0.63 to 0.79) | < 0.0001 | 0.48 (0.32 to 0.73) | 0.0005 |
T stage | ||||||
 T0 | Reference |  | Reference |  |  |  |
 T1 | 0.63 (0.37 to 1.09) | 0.1007 | 1.39 (0.78 to 2.48) | 0.2709 | Reference |  |
 T2 | 1.02 (0.59 to 1.75) | 0.9435 | 1.74 (0.98 to 3.09) | 0.0588 | 0.78 (0.61 to 1.00) | 0.0517 |
 T3 | 1.28 (0.73 to 2.24) | 0.3910 | 3.52 (1.94 to 6.39) | < 0.0001 | 0.75 (0.48 to 1.17) | 0.2040 |
 T4 | 1.00 (0.58 to 1.70) | 0.9861 | 1.65 (0.93 to 2.93) | 0.0862 | 0.20 (0.15 to 0.27) | < 0.0001 |
 Unknown | 0.74 (0.42 to 1.29) | 0.2909 | 1.06 (0.58 to 1.92) | 0.8544 | 0.97 (0.46 to 2.03) | 0.9319 |
N stage | ||||||
 N0 | Reference |  | Reference |  | Reference |  |
 N1 | 2.72 (2.37 to 3.12) | < 0.0001 | 1.07 (0.93 to 1.24) | 0.34 | 0.97 (0.72 to 1.30) | 0.8284 |
 N2 | 2.22 (1.99 to 2.48) | < 0.0001 | 1.66 (1.51 to 1.82) | < 0.0001 | 0.13 (0.1 to 0.17) | < 0.0001 |
 N3 | 2.36 (2.08 to 2.67) | < 0.0001 | 1.73 (1.55 to 1.92) | < 0.0001 | 0.02 (0.01 to 0.03) | < 0.0001 |
 Unknown | 1.05 (0.84 to 1.32) | 0.6623 | 0.68 (0.56 to 0.82) | < 0.0001 | 0.28 (0.15 to 0.51) | < 0.0001 |
M stage | ||||||
 M0 | Reference |  | Reference |  | Reference |  |
 M1 | 0.65 (0.6 to 0.71) | < 0.0001 | 0.35 (0.32 to 0.37) | < 0.0001 | 0.03 (0.02 to 0.04) | < 0.0001 |
 Unknown | 0.29 (0.18 to 0.45) | < 0.0001 | 0.28 (0.20 to 0.39) | < 0.0001 | 1.34 (0.61 to 2.92) | 0.4665 |
Laterality | ||||||
 Bilateral | Reference |  | Reference |  | Reference |  |
 Left | 0.62 (0.43 to 0.88) | 0.0071 | 3.46 (2.13 to 5.63) | < 0.0001 | 5.62 (0.69 to 45.6) | 0.1063 |
 Right | 0.56 (0.39 to 0.79) | 0.0012 | 3.59 (2.21 to 5.83) | < 0.0001 | 5.63 (0.69 to 45.6) | 0.1058 |
 Unknown | 0.47 (0.30 to 0.74) | 0.0012 | 1.82 (1.03 to 3.22) | 0.0397 |  |  |
Chemotherapy | ||||||
 0 |  |  | Reference |  | Reference |  |
 1 |  |  | 1.21 (1.11 to 1.31) | < 0.0001 | 1.85 (1.45 to 2.35) | < 0.0001 |
Surgery type | ||||||
 Segmental | Reference |  | Reference |  |  |  |
 Non-surgery | 1.32 (1.13 to 1.55) | 0.0006 | 36.5 (29.3 to 45.48) | < 0.0001 |  |  |
 Pneumonectomy | 1.80 (1.34 to 2.41) | < 0.0001 | 0.43 (0.20 to 0.95) | 0.0363 |  |  |
Radiation | ||||||
 0 | Reference |  |  |  | Reference |  |
 1 | 1.18 (1.08 to 1.28) | 0.0001 |  |  | 0.05 (0.04 to 0.07) | < 0.0001 |
Immunotherapy | ||||||
 0 | Reference |  | Reference |  | Reference |  |
 1 | 4.06 (1.53 to 10.8) | 0.0050 | 0.79 (0.29 to 2.1) | 0.6303 | 0.02 (0.00 to 0.31) | 0.0045 |
Institution type | ||||||
 Academic | Reference |  | Reference |  | Reference |  |
 Community | 0.81 (0.74 to 0.89) | < 0.0001 | 0.90 (0.83 to 0.98) | 0.0097 | 0.00 (0.00 to 0.01) | < 0.0001 |
Driving time (hours) | ||||||
 1 | Reference |  | Reference |  | Reference |  |
 2 | 0.88 (0.77 to 1.00) | 0.0563 | 0.97 (0.86 to 1.1) | 0.6531 | 1.93 (1.17 to 3.19) | 0.0097 |
  > 2 | 0.92 (0.75 to 1.12) | 0.4131 | 0.90 (0.74 to 1.08) | 0.2578 | 1.05 (0.53 to 2.08) | 0.8908 |
Health Zone | ||||||
 Calgary | Reference |  | Reference |  | Reference |  |
 Central | 1.36 (1.19 to 1.56) | < 0.0001 | 0.75 (0.66 to 0.85) | < 0.0001 | 5.21 (3.26 to 8.34) | < 0.0001 |
 Edmonton | 0.97 (0.89 to 1.06) | 0.5263 | 0.99 (0.91 to 1.08) | 0.8189 | 1.90 (1.52 to 2.36) | < 0.0001 |
 North | 1.17 (0.95 to 1.44) | 0.1448 | 0.94 (0.77 to 1.15) | 0.5443 | 6.86 (3.40 to 13.85) | < 0.0001 |
 South | 1.29 (1.10 to 1.52) | 0.0019 | 0.92 (0.79 to 1.06) | 0.2432 | 2.66 (1.38 to 5.16) | 0.0036 |
Education levela | ||||||
  < = 80% | Reference |  | Reference |  | Reference |  |
  > 80% | 1.06 (0.98 to 1.15) | 0.1557 | 1.00 (0.92 to 1.08) | 0.9480 | 0.94 (0.75 to 1.18) | 0.6046 |
Income level | ||||||
  < = 46 k | Reference |  | Reference |  | Reference |  |
  > 46 k | 1.21 (1.12 to 1.32) | < 0.0001 | 1.03 (0.95 to 1.11) | 0.4565 | 1.35 (1.09 to 1.67) | 0.0069 |