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Table 3 Multivariable Logistic regression for factors associated with surgery, chemotherapy, and radiation therapy in patients with lung cancer

From: Impact of pre-existing cardiovascular disease on treatment patterns and survival outcomes in patients with lung cancer

Variable

Chemotherapy

Radiation

Surgery

Odds Ratio (95% Confidence Limit)

P value

Odds Ratio (95% Confidence Limit)

P value

Odds Ratio (95% Confidence Limit)

P value

Age group

  < =60

Reference

 

Reference

 

Reference

 

 61–70

0.68 (0.62 to 0.75)

< 0.0001

0.82 (0.74 to 0.9)

< 0.0001

0.57 (0.44 to 0.75)

< 0.0001

 71–80

0.34 (0.30 to 0.37)

< 0.0001

0.61 (0.55 to 0.67)

< 0.0001

0.35 (0.27 to 0.46)

< 0.0001

  > 80

0.09 (0.08 to 0.11)

< 0.0001

0.38 (0.34 to 0.43)

< 0.0001

0.12 (0.08 to 0.18)

< 0.0001

Sex

 Female

Reference

 

Reference

 

Reference

 

 Male

0.92 (0.85 to 0.99)

0.0225

1.11 (1.04 to 1.18)

0.0029

0.99 (0.82 to 1.21)

0.9448

Year of diagnosis

1.01 (1 to 1.02)

0.0337

1.00 (0.99 to 1.01)

0.6327

0.99 (0.96 to 1.02)

0.4833

CCI score

 0

Reference

 

Reference

 

Reference

 

 1

0.77 (0.67 to 0.89)

0.0002

1.02 (0.89 to 1.17)

0.7471

0.79 (0.55 to 1.13)

0.1945

  > 1

0.68 (0.61 to 0.75)

< 0.0001

1.16 (1.04 to 1.29)

0.0058

0.68 (0.52 to 0.9)

0.0078

Cardiovascular disease

 No

Reference

 

Reference

 

Reference

 

 Yes

0.53 (0.48 to 0.58)

< 0.0001

0.76 (0.70 to 0.82)

< 0.0001

0.56 (0.44 to 0.7)

< 0.0001

Histology

 Adenocarcinoma

Reference

 

Reference

 

Reference

 

 SCC

0.61 (0.55 to 0.68)

< 0.0001

0.77 (0.71 to 0.85)

< 0.0001

0.12 (0.08 to 0.16)

< 0.0001

 SCLC

6.64 (5.93 to 7.45)

< 0.0001

2.17 (1.96 to 2.39)

< 0.0001

0.47 (0.37 to 0.61)

< 0.0001

 Carcinoid/LCNE

1.05 (0.84 to 1.31)

0.6779

0.82 (0.62 to 1.08)

0.1480

3.46 (2.16 to 5.54)

< 0.0001

 Large cell ca

0.79 (0.58 to 1.08)

0.1382

1.98 (1.45 to 2.71)

< 0.0001

9.65 (4.74 to 19.6)

< 0.0001

 Others

6.64 (5.93 to 7.45)

< 0.0001

0.71 (0.63 to 0.79)

< 0.0001

0.48 (0.32 to 0.73)

0.0005

T stage

 T0

Reference

 

Reference

   

 T1

0.63 (0.37 to 1.09)

0.1007

1.39 (0.78 to 2.48)

0.2709

Reference

 

 T2

1.02 (0.59 to 1.75)

0.9435

1.74 (0.98 to 3.09)

0.0588

0.78 (0.61 to 1.00)

0.0517

 T3

1.28 (0.73 to 2.24)

0.3910

3.52 (1.94 to 6.39)

< 0.0001

0.75 (0.48 to 1.17)

0.2040

 T4

1.00 (0.58 to 1.70)

0.9861

1.65 (0.93 to 2.93)

0.0862

0.20 (0.15 to 0.27)

< 0.0001

 Unknown

0.74 (0.42 to 1.29)

0.2909

1.06 (0.58 to 1.92)

0.8544

0.97 (0.46 to 2.03)

0.9319

N stage

 N0

Reference

 

Reference

 

Reference

 

 N1

2.72 (2.37 to 3.12)

< 0.0001

1.07 (0.93 to 1.24)

0.34

0.97 (0.72 to 1.30)

0.8284

 N2

2.22 (1.99 to 2.48)

< 0.0001

1.66 (1.51 to 1.82)

< 0.0001

0.13 (0.1 to 0.17)

< 0.0001

 N3

2.36 (2.08 to 2.67)

< 0.0001

1.73 (1.55 to 1.92)

< 0.0001

0.02 (0.01 to 0.03)

< 0.0001

 Unknown

1.05 (0.84 to 1.32)

0.6623

0.68 (0.56 to 0.82)

< 0.0001

0.28 (0.15 to 0.51)

< 0.0001

M stage

 M0

Reference

 

Reference

 

Reference

 

 M1

0.65 (0.6 to 0.71)

< 0.0001

0.35 (0.32 to 0.37)

< 0.0001

0.03 (0.02 to 0.04)

< 0.0001

 Unknown

0.29 (0.18 to 0.45)

< 0.0001

0.28 (0.20 to 0.39)

< 0.0001

1.34 (0.61 to 2.92)

0.4665

Laterality

 Bilateral

Reference

 

Reference

 

Reference

 

 Left

0.62 (0.43 to 0.88)

0.0071

3.46 (2.13 to 5.63)

< 0.0001

5.62 (0.69 to 45.6)

0.1063

 Right

0.56 (0.39 to 0.79)

0.0012

3.59 (2.21 to 5.83)

< 0.0001

5.63 (0.69 to 45.6)

0.1058

 Unknown

0.47 (0.30 to 0.74)

0.0012

1.82 (1.03 to 3.22)

0.0397

  

Chemotherapy

 0

  

Reference

 

Reference

 

 1

  

1.21 (1.11 to 1.31)

< 0.0001

1.85 (1.45 to 2.35)

< 0.0001

Surgery type

 Segmental

Reference

 

Reference

   

 Non-surgery

1.32 (1.13 to 1.55)

0.0006

36.5 (29.3 to 45.48)

< 0.0001

  

 Pneumonectomy

1.80 (1.34 to 2.41)

< 0.0001

0.43 (0.20 to 0.95)

0.0363

  

Radiation

 0

Reference

   

Reference

 

 1

1.18 (1.08 to 1.28)

0.0001

  

0.05 (0.04 to 0.07)

< 0.0001

Immunotherapy

 0

Reference

 

Reference

 

Reference

 

 1

4.06 (1.53 to 10.8)

0.0050

0.79 (0.29 to 2.1)

0.6303

0.02 (0.00 to 0.31)

0.0045

Institution type

 Academic

Reference

 

Reference

 

Reference

 

 Community

0.81 (0.74 to 0.89)

< 0.0001

0.90 (0.83 to 0.98)

0.0097

0.00 (0.00 to 0.01)

< 0.0001

Driving time (hours)

 1

Reference

 

Reference

 

Reference

 

 2

0.88 (0.77 to 1.00)

0.0563

0.97 (0.86 to 1.1)

0.6531

1.93 (1.17 to 3.19)

0.0097

  > 2

0.92 (0.75 to 1.12)

0.4131

0.90 (0.74 to 1.08)

0.2578

1.05 (0.53 to 2.08)

0.8908

Health Zone

 Calgary

Reference

 

Reference

 

Reference

 

 Central

1.36 (1.19 to 1.56)

< 0.0001

0.75 (0.66 to 0.85)

< 0.0001

5.21 (3.26 to 8.34)

< 0.0001

 Edmonton

0.97 (0.89 to 1.06)

0.5263

0.99 (0.91 to 1.08)

0.8189

1.90 (1.52 to 2.36)

< 0.0001

 North

1.17 (0.95 to 1.44)

0.1448

0.94 (0.77 to 1.15)

0.5443

6.86 (3.40 to 13.85)

< 0.0001

 South

1.29 (1.10 to 1.52)

0.0019

0.92 (0.79 to 1.06)

0.2432

2.66 (1.38 to 5.16)

0.0036

Education levela

  < = 80%

Reference

 

Reference

 

Reference

 

  > 80%

1.06 (0.98 to 1.15)

0.1557

1.00 (0.92 to 1.08)

0.9480

0.94 (0.75 to 1.18)

0.6046

Income level

  < = 46 k

Reference

 

Reference

 

Reference

 

  > 46 k

1.21 (1.12 to 1.32)

< 0.0001

1.03 (0.95 to 1.11)

0.4565

1.35 (1.09 to 1.67)

0.0069

  1. CCI Charlson’s comorbidity index, SCC Squamous cell cancer, SCLC Small cell lung cancer, LCNE Large Cell Neuroendocrine tumor. a80% of residents have high school and above level of education in the neighborhood
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