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Table 3 Multivariable Logistic regression for factors associated with surgery, chemotherapy, and radiation therapy in patients with lung cancer

From: Impact of pre-existing cardiovascular disease on treatment patterns and survival outcomes in patients with lung cancer

Variable Chemotherapy Radiation Surgery
Odds Ratio (95% Confidence Limit) P value Odds Ratio (95% Confidence Limit) P value Odds Ratio (95% Confidence Limit) P value
Age group
  < =60 Reference   Reference   Reference  
 61–70 0.68 (0.62 to 0.75) < 0.0001 0.82 (0.74 to 0.9) < 0.0001 0.57 (0.44 to 0.75) < 0.0001
 71–80 0.34 (0.30 to 0.37) < 0.0001 0.61 (0.55 to 0.67) < 0.0001 0.35 (0.27 to 0.46) < 0.0001
  > 80 0.09 (0.08 to 0.11) < 0.0001 0.38 (0.34 to 0.43) < 0.0001 0.12 (0.08 to 0.18) < 0.0001
Sex
 Female Reference   Reference   Reference  
 Male 0.92 (0.85 to 0.99) 0.0225 1.11 (1.04 to 1.18) 0.0029 0.99 (0.82 to 1.21) 0.9448
Year of diagnosis 1.01 (1 to 1.02) 0.0337 1.00 (0.99 to 1.01) 0.6327 0.99 (0.96 to 1.02) 0.4833
CCI score
 0 Reference   Reference   Reference  
 1 0.77 (0.67 to 0.89) 0.0002 1.02 (0.89 to 1.17) 0.7471 0.79 (0.55 to 1.13) 0.1945
  > 1 0.68 (0.61 to 0.75) < 0.0001 1.16 (1.04 to 1.29) 0.0058 0.68 (0.52 to 0.9) 0.0078
Cardiovascular disease
 No Reference   Reference   Reference  
 Yes 0.53 (0.48 to 0.58) < 0.0001 0.76 (0.70 to 0.82) < 0.0001 0.56 (0.44 to 0.7) < 0.0001
Histology
 Adenocarcinoma Reference   Reference   Reference  
 SCC 0.61 (0.55 to 0.68) < 0.0001 0.77 (0.71 to 0.85) < 0.0001 0.12 (0.08 to 0.16) < 0.0001
 SCLC 6.64 (5.93 to 7.45) < 0.0001 2.17 (1.96 to 2.39) < 0.0001 0.47 (0.37 to 0.61) < 0.0001
 Carcinoid/LCNE 1.05 (0.84 to 1.31) 0.6779 0.82 (0.62 to 1.08) 0.1480 3.46 (2.16 to 5.54) < 0.0001
 Large cell ca 0.79 (0.58 to 1.08) 0.1382 1.98 (1.45 to 2.71) < 0.0001 9.65 (4.74 to 19.6) < 0.0001
 Others 6.64 (5.93 to 7.45) < 0.0001 0.71 (0.63 to 0.79) < 0.0001 0.48 (0.32 to 0.73) 0.0005
T stage
 T0 Reference   Reference    
 T1 0.63 (0.37 to 1.09) 0.1007 1.39 (0.78 to 2.48) 0.2709 Reference  
 T2 1.02 (0.59 to 1.75) 0.9435 1.74 (0.98 to 3.09) 0.0588 0.78 (0.61 to 1.00) 0.0517
 T3 1.28 (0.73 to 2.24) 0.3910 3.52 (1.94 to 6.39) < 0.0001 0.75 (0.48 to 1.17) 0.2040
 T4 1.00 (0.58 to 1.70) 0.9861 1.65 (0.93 to 2.93) 0.0862 0.20 (0.15 to 0.27) < 0.0001
 Unknown 0.74 (0.42 to 1.29) 0.2909 1.06 (0.58 to 1.92) 0.8544 0.97 (0.46 to 2.03) 0.9319
N stage
 N0 Reference   Reference   Reference  
 N1 2.72 (2.37 to 3.12) < 0.0001 1.07 (0.93 to 1.24) 0.34 0.97 (0.72 to 1.30) 0.8284
 N2 2.22 (1.99 to 2.48) < 0.0001 1.66 (1.51 to 1.82) < 0.0001 0.13 (0.1 to 0.17) < 0.0001
 N3 2.36 (2.08 to 2.67) < 0.0001 1.73 (1.55 to 1.92) < 0.0001 0.02 (0.01 to 0.03) < 0.0001
 Unknown 1.05 (0.84 to 1.32) 0.6623 0.68 (0.56 to 0.82) < 0.0001 0.28 (0.15 to 0.51) < 0.0001
M stage
 M0 Reference   Reference   Reference  
 M1 0.65 (0.6 to 0.71) < 0.0001 0.35 (0.32 to 0.37) < 0.0001 0.03 (0.02 to 0.04) < 0.0001
 Unknown 0.29 (0.18 to 0.45) < 0.0001 0.28 (0.20 to 0.39) < 0.0001 1.34 (0.61 to 2.92) 0.4665
Laterality
 Bilateral Reference   Reference   Reference  
 Left 0.62 (0.43 to 0.88) 0.0071 3.46 (2.13 to 5.63) < 0.0001 5.62 (0.69 to 45.6) 0.1063
 Right 0.56 (0.39 to 0.79) 0.0012 3.59 (2.21 to 5.83) < 0.0001 5.63 (0.69 to 45.6) 0.1058
 Unknown 0.47 (0.30 to 0.74) 0.0012 1.82 (1.03 to 3.22) 0.0397   
Chemotherapy
 0    Reference   Reference  
 1    1.21 (1.11 to 1.31) < 0.0001 1.85 (1.45 to 2.35) < 0.0001
Surgery type
 Segmental Reference   Reference    
 Non-surgery 1.32 (1.13 to 1.55) 0.0006 36.5 (29.3 to 45.48) < 0.0001   
 Pneumonectomy 1.80 (1.34 to 2.41) < 0.0001 0.43 (0.20 to 0.95) 0.0363   
Radiation
 0 Reference     Reference  
 1 1.18 (1.08 to 1.28) 0.0001    0.05 (0.04 to 0.07) < 0.0001
Immunotherapy
 0 Reference   Reference   Reference  
 1 4.06 (1.53 to 10.8) 0.0050 0.79 (0.29 to 2.1) 0.6303 0.02 (0.00 to 0.31) 0.0045
Institution type
 Academic Reference   Reference   Reference  
 Community 0.81 (0.74 to 0.89) < 0.0001 0.90 (0.83 to 0.98) 0.0097 0.00 (0.00 to 0.01) < 0.0001
Driving time (hours)
 1 Reference   Reference   Reference  
 2 0.88 (0.77 to 1.00) 0.0563 0.97 (0.86 to 1.1) 0.6531 1.93 (1.17 to 3.19) 0.0097
  > 2 0.92 (0.75 to 1.12) 0.4131 0.90 (0.74 to 1.08) 0.2578 1.05 (0.53 to 2.08) 0.8908
Health Zone
 Calgary Reference   Reference   Reference  
 Central 1.36 (1.19 to 1.56) < 0.0001 0.75 (0.66 to 0.85) < 0.0001 5.21 (3.26 to 8.34) < 0.0001
 Edmonton 0.97 (0.89 to 1.06) 0.5263 0.99 (0.91 to 1.08) 0.8189 1.90 (1.52 to 2.36) < 0.0001
 North 1.17 (0.95 to 1.44) 0.1448 0.94 (0.77 to 1.15) 0.5443 6.86 (3.40 to 13.85) < 0.0001
 South 1.29 (1.10 to 1.52) 0.0019 0.92 (0.79 to 1.06) 0.2432 2.66 (1.38 to 5.16) 0.0036
Education levela
  < = 80% Reference   Reference   Reference  
  > 80% 1.06 (0.98 to 1.15) 0.1557 1.00 (0.92 to 1.08) 0.9480 0.94 (0.75 to 1.18) 0.6046
Income level
  < = 46 k Reference   Reference   Reference  
  > 46 k 1.21 (1.12 to 1.32) < 0.0001 1.03 (0.95 to 1.11) 0.4565 1.35 (1.09 to 1.67) 0.0069
  1. CCI Charlson’s comorbidity index, SCC Squamous cell cancer, SCLC Small cell lung cancer, LCNE Large Cell Neuroendocrine tumor. a80% of residents have high school and above level of education in the neighborhood
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