Table 1 Baseline characteristics of patients with lung cancer
Variables | Total (N = 20,689), n (%) | With cardiovascular disease (N = 6436), n (%) | Without cardiovascular disease (N = 14,253), n (%) | P-value |
|---|---|---|---|---|
Age, in years |  |  |  | < 0.0001 |
 Mean (+STD) | 69.5 (±11) | 73.7 (±9.7) | 67.6 (±11.1) |  |
 Median (IQR) | 70 (62–78) | 75 (67–81) | 68 (60–76) |  |
Age group |  |  |  | < 0.0001 |
  < =60 | 4443 (21.5%) | 658 (10.2%) | 3785 (26.6%) |  |
 61–70 | 6112 (29.5%) | 1549 (24.1%) | 4563 (32%) |  |
 71–80 | 6717 (32.5%) | 2590 (40.2%) | 4127 (29%) |  |
  > 80 | 3417 (16.5%) | 1639 (25.5%) | 1778 (12.5%) |  |
Sex |  |  |  | < 0.0001 |
 Female | 10,156 (49.1%) | 2874 (44.7%) | 7282 (51.1%) |  |
 Male | 10,533 (50.9%) | 3562 (55.3%) | 6971 (48.9%) |  |
Year of diagnosis | Â | Â | Â | 0.0337 |
 2004–2009 | 9993 (48.3%) | 3038 (47.2%) | 6955 (48.8%) |  |
 2010–2015 | 10,696 (51.7%) | 3398 (52.8%) | 7298 (51.2%) |  |
CCI score |  |  |  | < 0.0001 |
 0 | 2566 (12.4%) | 310 (4.8%) | 2256 (15.8%) |  |
 1 | 2614 (12.6%) | 627 (9.7%) | 1987 (13.9%) |  |
  > 1 | 15,509 (75%) | 5499 (85.4%) | 10,010 (70.2%) |  |
Histology |  |  |  | < 0.0001 |
 Adenocarcinoma | 7727 (37.3%) | 2024 (31.4%) | 5703 (40%) |  |
 SCC | 3680 (17.8%) | 1184 (18.4%) | 2496 (17.5%) |  |
 SCLC | 2571 (12.4%) | 799 (12.4%) | 1772 (12.4%) |  |
 Carcinoid/LCNE | 520 (2.5%) | 117 (1.8%) | 403 (2.8%) |  |
 Large cell cancer | 260 (1.3%) | 59 (0.9%) | 201 (1.4%) |  |
 Others | 5931 (28.7%) | 2253 (35%) | 3678 (25.8%) |  |
Stage | ||||
 I | 3636 (17.6%) | 1127 (17.5%) | 2509 (17.6%) | < 0.0001 |
 II | 880 (4.3%) | 250 (3.9%) | 630 (4.4%) |  |
 III | 5168 (25%) | 1591 (24.7%) | 3577 (25.1%) |  |
 IV | 10,409 (50.3%) | 3207 (49.8%) | 7202 (50.5%) |  |
 Unknown | 596 (2.9%) | 261 (4.1%) | 335 (2.4%) |  |
T stage | ||||
 T0 | 110 (0.5%) | 44 (0.7%) | 66 (0.5%) | < 0.0001 |
 T1 | 3095 (15%) | 985 (15.3%) | 2110 (14.8%) |  |
 T2 | 6581 (31.8%) | 2001 (31.1%) | 4580 (32.1%) |  |
 T3 | 788 (3.8%) | 188 (2.9%) | 600 (4.2%) |  |
 T4 | 9378 (45.3%) | 2966 (46.1%) | 6412 (45%) |  |
 Unknown | 737 (3.6%) | 252 (3.9%) | 485 (3.4%) |  |
N stage | ||||
 N0 | 6540 (31.6%) | 2126 (33%) | 4414 (31%) | < 0.0001 |
 N1 | 1729 (8.4%) | 494 (7.7%) | 1235 (8.7%) |  |
 N2 | 7453 (36%) | 2302 (35.8%) | 5151 (36.1%) |  |
 N3 | 3803 (18.4%) | 1073 (16.7%) | 2730 (19.2%) |  |
 Unknown | 1164 (5.6%) | 441 (6.9%) | 723 (5.1%) |  |
M stage | ||||
 M0 | 9877 (47.7%) | 3069 (47.7%) | 6808 (47.8%) | 0.0008 |
 M1 | 10,409 (50.3%) | 3207 (49.8%) | 7202 (50.5%) |  |
 Unknown | 403 (1.9%) | 160 (2.5%) | 243 (1.7%) |  |
Laterality | ||||
 Bilateral | 211 (1%) | 74 (1.1%) | 137 (1%) | 0.0003 |
 Left | 8477 (41%) | 2677 (41.6%) | 5800 (40.7%) |  |
 Right | 11,568 (55.9%) | 3515 (54.6%) | 8053 (56.5%) |  |
 Unknown | 433 (2.1%) | 170 (2.6%) | 263 (1.8%) |  |
Surgery | ||||
 No | 17,274 (83.5%) | 5721 (88.9%) | 11,553 (81.1%) | < 0.0001 |
 Lobectomy or segmental | 3168 (15.3%) | 686 (10.7%) | 2482 (17.4%) |  |
 Pneumonectomy | 247 (1.2%) | 29 (0.5%) | 218 (1.5%) |  |
Chemotherapy | ||||
 No | 15,029 (72.6%) | 5378 (83.6%) | 9651 (67.7%) | < 0.0001 |
 Yes | 5660 (27.4%) | 1058 (16.4%) | 4602 (32.3%) |  |
Immunotherapy | ||||
 No | 20,669 (99.9%) | 6433 (100%) | 14,236 (99.9%) | 0.1195 |
 Yes | 20 (0.1%) | 3 (0%) | 17 (0.1%) |  |
Radiation | ||||
 No | 14,418 (69.7%) | 4743 (73.7%) | 9675 (67.9%) | < 0.0001 |
 Yes | 6271 (30.3%) | 1693 (26.3%) | 4578 (32.1%) |  |
Institution type | ||||
 Academic | 10,713 (51.8%) | 3119 (48.5%) | 7594 (53.3%) | < 0.0001 |
 Community | 9976 (48.2%) | 3317 (51.5%) | 6659 (46.7%) |  |
Driving time (hours) | ||||
 1 | 15,419 (74.5%) | 4704 (73.1%) | 10,715 (75.2%) | < 0.0001 |
 2 | 2885 (13.9%) | 1010 (15.7%) | 1875 (13.2%) |  |
  > 2 | 2385 (11.5%) | 722 (11.2%) | 1663 (11.7%) |  |
Health Zone | ||||
 Calgary | 6192 (29.9%) | 1781 (27.7%) | 4411 (30.9%) | < 0.0001 |
 Central | 3125 (15.1%) | 1045 (16.2%) | 2080 (14.6%) |  |
 Edmonton | 7159 (34.6%) | 2239 (34.8%) | 4920 (34.5%) |  |
 North | 2459 (11.9%) | 755 (11.7%) | 1704 (12%) |  |
 South | 1754 (8.5%) | 616 (9.6%) | 1138 (8%) |  |
Educational levela | ||||
  < = 80% | 10,133 (49%) | 3281 (51%) | 6852 (48.1%) | 0.0005 |
  > 80% | 10,527 (50.9%) | 3147 (48.9%) | 7380 (51.8%) |  |
 Unknown | 29 (0.1%) | 8 (0.1%) | 21 (0.1%) |  |
Income level | ||||
  < = 46 k | 12,849 (62.1%) | 4085 (63.5%) | 8764 (61.5%) | 0.0237 |
  > 46 k | 7811 (37.8%) | 2343 (36.4%) | 5468 (38.4%) |  |
 Unknown | 29 (0.1%) | 8 (0.1%) | 21 (0.1%) |  |