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Table 1 Baseline characteristics of patients with lung cancer

From: Impact of pre-existing cardiovascular disease on treatment patterns and survival outcomes in patients with lung cancer

Variables Total (N = 20,689),
n (%)
With cardiovascular disease (N = 6436),
n (%)
Without cardiovascular disease (N = 14,253),
n (%)
P-value
Age, in years     < 0.0001
 Mean (+STD) 69.5 (±11) 73.7 (±9.7) 67.6 (±11.1)  
 Median (IQR) 70 (62–78) 75 (67–81) 68 (60–76)  
Age group     < 0.0001
  < =60 4443 (21.5%) 658 (10.2%) 3785 (26.6%)  
 61–70 6112 (29.5%) 1549 (24.1%) 4563 (32%)  
 71–80 6717 (32.5%) 2590 (40.2%) 4127 (29%)  
  > 80 3417 (16.5%) 1639 (25.5%) 1778 (12.5%)  
Sex     < 0.0001
 Female 10,156 (49.1%) 2874 (44.7%) 7282 (51.1%)  
 Male 10,533 (50.9%) 3562 (55.3%) 6971 (48.9%)  
Year of diagnosis     0.0337
 2004–2009 9993 (48.3%) 3038 (47.2%) 6955 (48.8%)  
 2010–2015 10,696 (51.7%) 3398 (52.8%) 7298 (51.2%)  
CCI score     < 0.0001
 0 2566 (12.4%) 310 (4.8%) 2256 (15.8%)  
 1 2614 (12.6%) 627 (9.7%) 1987 (13.9%)  
  > 1 15,509 (75%) 5499 (85.4%) 10,010 (70.2%)  
Histology     < 0.0001
 Adenocarcinoma 7727 (37.3%) 2024 (31.4%) 5703 (40%)  
 SCC 3680 (17.8%) 1184 (18.4%) 2496 (17.5%)  
 SCLC 2571 (12.4%) 799 (12.4%) 1772 (12.4%)  
 Carcinoid/LCNE 520 (2.5%) 117 (1.8%) 403 (2.8%)  
 Large cell cancer 260 (1.3%) 59 (0.9%) 201 (1.4%)  
 Others 5931 (28.7%) 2253 (35%) 3678 (25.8%)  
Stage
 I 3636 (17.6%) 1127 (17.5%) 2509 (17.6%) < 0.0001
 II 880 (4.3%) 250 (3.9%) 630 (4.4%)  
 III 5168 (25%) 1591 (24.7%) 3577 (25.1%)  
 IV 10,409 (50.3%) 3207 (49.8%) 7202 (50.5%)  
 Unknown 596 (2.9%) 261 (4.1%) 335 (2.4%)  
T stage
 T0 110 (0.5%) 44 (0.7%) 66 (0.5%) < 0.0001
 T1 3095 (15%) 985 (15.3%) 2110 (14.8%)  
 T2 6581 (31.8%) 2001 (31.1%) 4580 (32.1%)  
 T3 788 (3.8%) 188 (2.9%) 600 (4.2%)  
 T4 9378 (45.3%) 2966 (46.1%) 6412 (45%)  
 Unknown 737 (3.6%) 252 (3.9%) 485 (3.4%)  
N stage
 N0 6540 (31.6%) 2126 (33%) 4414 (31%) < 0.0001
 N1 1729 (8.4%) 494 (7.7%) 1235 (8.7%)  
 N2 7453 (36%) 2302 (35.8%) 5151 (36.1%)  
 N3 3803 (18.4%) 1073 (16.7%) 2730 (19.2%)  
 Unknown 1164 (5.6%) 441 (6.9%) 723 (5.1%)  
M stage
 M0 9877 (47.7%) 3069 (47.7%) 6808 (47.8%) 0.0008
 M1 10,409 (50.3%) 3207 (49.8%) 7202 (50.5%)  
 Unknown 403 (1.9%) 160 (2.5%) 243 (1.7%)  
Laterality
 Bilateral 211 (1%) 74 (1.1%) 137 (1%) 0.0003
 Left 8477 (41%) 2677 (41.6%) 5800 (40.7%)  
 Right 11,568 (55.9%) 3515 (54.6%) 8053 (56.5%)  
 Unknown 433 (2.1%) 170 (2.6%) 263 (1.8%)  
Surgery
 No 17,274 (83.5%) 5721 (88.9%) 11,553 (81.1%) < 0.0001
 Lobectomy or segmental 3168 (15.3%) 686 (10.7%) 2482 (17.4%)  
 Pneumonectomy 247 (1.2%) 29 (0.5%) 218 (1.5%)  
Chemotherapy
 No 15,029 (72.6%) 5378 (83.6%) 9651 (67.7%) < 0.0001
 Yes 5660 (27.4%) 1058 (16.4%) 4602 (32.3%)  
Immunotherapy
 No 20,669 (99.9%) 6433 (100%) 14,236 (99.9%) 0.1195
 Yes 20 (0.1%) 3 (0%) 17 (0.1%)  
Radiation
 No 14,418 (69.7%) 4743 (73.7%) 9675 (67.9%) < 0.0001
 Yes 6271 (30.3%) 1693 (26.3%) 4578 (32.1%)  
Institution type
 Academic 10,713 (51.8%) 3119 (48.5%) 7594 (53.3%) < 0.0001
 Community 9976 (48.2%) 3317 (51.5%) 6659 (46.7%)  
Driving time (hours)
 1 15,419 (74.5%) 4704 (73.1%) 10,715 (75.2%) < 0.0001
 2 2885 (13.9%) 1010 (15.7%) 1875 (13.2%)  
  > 2 2385 (11.5%) 722 (11.2%) 1663 (11.7%)  
Health Zone
 Calgary 6192 (29.9%) 1781 (27.7%) 4411 (30.9%) < 0.0001
 Central 3125 (15.1%) 1045 (16.2%) 2080 (14.6%)  
 Edmonton 7159 (34.6%) 2239 (34.8%) 4920 (34.5%)  
 North 2459 (11.9%) 755 (11.7%) 1704 (12%)  
 South 1754 (8.5%) 616 (9.6%) 1138 (8%)  
Educational levela
  < = 80% 10,133 (49%) 3281 (51%) 6852 (48.1%) 0.0005
  > 80% 10,527 (50.9%) 3147 (48.9%) 7380 (51.8%)  
 Unknown 29 (0.1%) 8 (0.1%) 21 (0.1%)  
Income level
  < = 46 k 12,849 (62.1%) 4085 (63.5%) 8764 (61.5%) 0.0237
  > 46 k 7811 (37.8%) 2343 (36.4%) 5468 (38.4%)  
 Unknown 29 (0.1%) 8 (0.1%) 21 (0.1%)  
  1. STD Standard deviation, IQR Interquartile range, CCI Charlson’s comorbidity index, SCC Squamous cell cancer, SCLC Small cell lung cancer, LCNE Large Cell Neuroendocrine tumor. a80% of residents have high school and above level of education in the neighborhood