Table 1 Baseline values, ranges, and distributions for sensitivity analysis
Variable | Value | Range | Distribution |
|---|---|---|---|
AEs with fruquintinib | |||
 Hypertension  Hand-foot syndrome  Diarrhea  Platelet count decreased | 0.212 0.108 0.029 0.025 | 0.170 to 0.254 0.086 to 0.130 0.0232 to 0.0348 0.02 to 0.03 | Beta Beta Beta Beta |
AEs with best supportive care | |||
 Hypertension | 0.022 | 0.0176 to 0.0264 | Beta |
Cost of best supportive care | 1415.4 | 1022.8 to 2021.5 | Gamma |
Cost of fruquintinib after price negotiation | 1128.8 | 903.0 to 1354.5 | Gamma |
Cost of fruquintinib before price negotiation | 3408.5 | 2726.8 to 4090.2 | Gamma |
AE cost, USD | |||
 Hypertension  Hand-foot syndrome  Diarrhea  Platelet count decreased | 59.1 134.48 44.3 3551.7 | 47.28 to 70.92 107.58 to 161.38 28.5 to 54.6 3156.8 to 3980.2 | Gamma Gamma Gamma Gamma |
Utility | 0.66 | 0.59 to 0.735 | Beta |
AE duration, days | |||
 Hand-foot syndrome  Diarrhea | 14 5 | 11.2 to 16.8 4 to 6 | Gamma Gamma |
AE disutility | |||
 Hand-foot syndrome  Diarrhea | −0.116 −0.103 | −0.139 to − 0.093 − 0.123 to − 0.082 | Beta Beta |
Discount rate | 0.03 | 0.00 to 0.05 | Â |