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Table 1 Characteristics of all patients (N = 127)

From: Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients

Characteristics

Low risk (n = 69)

High risk (n = 58)

p value

Sex

  

0.852

 Male

55 (79.7%)

47 (81.0%)

 

 Female

16 (20.3%)

11 (19.0%)

 

Age, median (range)

11.8 (3.8–18.9)

12.2 (4.5–25.1)

0.606

Initial presentation

 Headache

35 (50.7%)

35 (60.3%)

0.278

 Vomiting

28 (40.6%)

28 (48.3%)

0.384

 Endocrine problems

21 (30.4%)

18 (31.0%)

0.942

 Visual problems

19 (27.9%)

19 (32.8%)

0.557

 Neurologic symptoms

20 (29.0%)

14 (24.1%)

0.539

Tumor location

  

0.223

 Pineal

24 (34.8%)

28 (47.5%)

 

 Sellar or suprasellar

14 (20.3%)

13 (22.0%)

 

 Thalamus or basal ganglia

17 (24.6%)

7 (11.9%)

 

 Ventricle

1 (1.4%)

1 (1.7%)

 

 Bifocal

10 (14.5%)

7 (11.9%)

 

 Multifocal

3 (4.3%)

1 (1.7%)

 

 Brain stem

0 (0.0%)

1 (1.7%)

 

Pathologic diagnosis

  

< 0.001

 Germinoma

66 (95.7%)

14 (23.7%)

 

 Immature teratoma

0 (0.0%)

5 (8.5%)

 

 Choriocarcinoma

0 (0.0%)

1 (1.7%)

 

 Mixed

0 (0.0%)

14 (23.7%)

 

 Unknown

3 (4.3%)

24 (40.7%)

 

Tumor seeding on MRI, Yes

7 (10.1%)

7 (12.3%)

0.704

Initial hydrocephalus, Yes

39 (56.5%)

30 (51.7%)

0.589

ETV, Yes

28 (40.6%)

23 (39.7%)

0.916

EVD, Yes

24 (34.8%)

14 (24.1%)

0.192

Initial EVD and subsequent VP shunt insertion, Yes

5 (7.2%)

6 (10.3%)

0.536

Direct VP shunt insertion, Yes

5 (7.2%)

4 (6.9%)

0.939

Operation due to growing teratoma, Yes

2 (2.9%)

12 (20.7%)

0.001

Follow-up year, median (range)

8.4 (0.3–14.1)

8.3 (0.2–14.2)

0.706

  1. NGGCT nongerminomatous germ cell tumor, MRI Magnetic resonance imaging, ETV endoscopic third ventriculostomy, EVD extraventricular drainage, VP ventriculoperitoneal