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Table 3 Anogenital SPCs in CIN 2–3 LLETZ treated women. A comparison between literature and our study data

From: Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

Author Year First lesion Value Vulva Vagina Anus
Evans [26] 2003 CIN 3 SIR 4.4 18.5 5.9
Kalliala [6] 2005 CIN 1–3 SIR 4.1 12 5.7
Edgren [9] 2007 CIN 3 IRR 2.2 6.7 4.7
Strander [22] 2007 CIN 3 RR   6.8  
Saleem [12] 2007 CIN3 SIR 16.4
   SCC SIR 6.2
Tatti [27] 2012 CIN 2–3 OR 1.91
Gaudet [10] 2014 CIN 2 SIR 1.47 3.61 0.89
   CIN 3 SIR 3.79 8.53 2.28
   CIN2–3 SIR 2.9 6.65 1.75
Sand [11] 2016 CIN 2 RR 2.5 8.1 2.9
   CIN 3 RR 4 17.1 4.2
Ebisch [8] 2017 CIN 3 IRR 4.97 86.08 3.85
Suk [23] 2018 SCC SIR 3.8 17.3 2.3
Acevedo Fontánez [14] 2018 SCC SIR 51.6
Wang [16] 2020 SCC SIR 2.29 1.85 1.41
Our study   CIN 2–3 SIR 1.7 12.4 1.8
  1. Legenda:
  2. CIN Cervical Intraepithelial Neoplasia
  3. IRR Incidence Rate Ratio
  4. LLETZ Large Loop Excision of the Transformation Zone
  5. RR Relative Risk
  6. SCC Invasive Squamous Cell Carcinoma