Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine

Table 3 Altered gene expression associated with exposure of cells to drugs, TXT and/or Ramucirumab

Genes	TXT			Ramucirumab			TXT + Ramucirumab
Genes	m_value	p_value	q_value	m_value	p_value	q_value	m_value	p_value	q_value
LK-2
*STXBP4*	−0.0220	0.8760	1.0000	−0.0330	0.8610	1.0000	−0.0970	0.5800	1.0000
*TP63*	1.0480	0.2390	1.0000	0.7020	0.4630	1.0000	0.1620	1.0000	1.0000
*TP53*	−0.0550	0.3770	1.0000	0.0710	0.6290	1.0000	−0.0180	0.9000	1.0000
*KDR*	0.0960	0.6650	1.0000	−0.0440	0.8800	1.0000	0.2760	0.2430	1.0000
*TUBB3*	0.0530	0.4340	1.0000	0.0560	0.7100	1.0000	0.0490	0.7310	1.0000
*STMN1*	0.0670	0.2820	1.0000	0.0860	0.5560	1.0000	0.1780	0.1970	1.0000
*CD274*	0.2700	0.3117	1.0000	0.1174	0.7383	1.0000	0.3239	0.2586	1.0000
RERF-LC-AI
*STXBP4*	0.2310	0.6750	1.0000	0.0840	0.9040	1.0000	−0.0240	0.9760	1.0000
*TP63*	2.5270	0.0001	0.0270	1.8600	0.0110	0.5420	2.0460	0.0087	0.4560
*TP53*	0.1150	0.8330	1.0000	0.0880	0.8950	1.0000	0.0850	0.9060	1.0000
*KDR*	1.3150	0.2730	1.0000	−0.2550	1.0000	1.0000	−0.1620	1.0000	1.0000
*TUBB3*	0.2040	0.6940	1.0000	0.8610	0.1720	1.0000	0.7020	0.3030	1.0000
*STMN1*	0.0420	0.9350	1.0000	1.6410	0.0104	0.5330	1.2510	0.0690	1.0000
*CD274*	−1.3328	0.0116	0.5476	−1.5704	0.0144	0.6156	−1.5697	0.0240	0.7406

m_value, log2 fold change (with and without treatment); q_value, false discovery rate (FDR)

ISSN: 1471-2407