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Table 3 Comparison of cellular factors levels between the studied groups

From: The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue

Cellular factors Patient with HPV + (N = 54), Group 1 Patient with HPV - (N = 48), Group 2 Control with HPV + (N = 12), Group 3 Control with HPV - (N = 36), Group 4 F.change, P* F.change, P+ F.change, P$
P53 3.7 ± 2.01 16.02 ± 6.34 2.75 ± 1.54 15.11 ± 4.48 0.24, < 0.001 1.06, 0.677 0.18, < 0.001
Rb 2.94 ± 1.85 12.5 ± 3.68 3.0 ± 2.29 15.78 ± 4.89 0.18, < 0.001 0.79, < 0.001 0.19, < 0.001
TGF_β 18.57 ± 6.76 5.81 ± 3.27 9.33 ± 3.60 7.72 ± 3.29 2.4, 0.637 0.75, 0.189 1.2, < 0.001
IL-11 19.09 ± 6.08 5.25 ± 3.85 20.75 ± 7.34 3.78 ± 2.19 5.05, < 0.001 1.38, 0.382 5.49, < 0.001
IL-6 15.19 ± 5.30 3.88 ± 3.56 16.0 ± 6.03 4.33 ± 1.93 3.51, < 0.001 0.89, 0.931 3.69, < 0.001
IL-1 16.19 ± 5.88 4.04 ± 2.54 17.42 ± 7.26 4.44 ± 2.13 3.64, < 0.001 0.9, 0.957 3.92, < 0.001
TNF_α 12.83 ± 5.97 3.54 ± 3.33 21.5 ± 6.97 3.81 ± 1.43 3.36, < 0.001 0.93, 0.988 5.64, < 0.001
NFK_B 13.02 ± 5.89 4.15 ± 4.42 20.58 ± 6.54 4.17 ± 2.07 3.12, < 0.001 0.99, 0.99 4.93, < 0.001
IFN-Alpha 16.94 ± 7.37 2.92 ± 3.58 17.75 ± 5.31 2.67 ± 1.19 6.34, < 0.001 1.09, 0.993 6.64, < 0.001
IFN-Beta 16.09 ± 6.53 2.73 ± 2.37 16.83 ± 6.01 2.86 ± 1.39 5.62, < 0.001 0.95, 0.998 5.88, < 0.001
PTPN13 2.91 ± 1.53 19.33 ± 4.84 5.25 ± 3.52 15.66 ± 3.89 0.18, < 0.001 1.23, < 0.001 0.33, < 0.001
E-cad 3.61 ± 1.82 4.88 ± 3.55 3.42 ± 0.99 9.17 ± 6.05 0.39, < 0.001 0.53, < 0.001 0.37, < 0.001
N-cad 23.48 ± 7.09 9.83 ± 4.27 18.33 ± 7.49 13.36 ± 5.89 1.75, 0.041 0.73, 0.025 1.37, 0.001
TWIST 28.43 ± 5.0 12.54 ± 5.50 23.58 ± 5.76 10.31 ± 6.23 2.75, < 0.001 1.22, 0.171 2.28, 0.001
ROS 17.37 ± 7.57 3.65 ± 2.93 19.25 ± 6.81 3.58 ± 1.93 4.85, < 0.001 1.02, 0.99 5.38, < 0.001
RNS 19.19 ± 8.43 4.48 ± 3.07 20.58 ± 6.06 4.14 ± 1.98 4.63, < 0.001 1.08, 0.987 4.97, < 0.001
SLUG 28.33 ± 5.59 14.08 ± 5.47 20.42 ± 6.11 9.28 ± 4.94 3.05, < 0.001 1.52, < 0.001 2.2, < 0.001
  1. F. change: Fold Change, Geometric Mean ± Standard Deviation, * comparison between group 1 versus group 4, + comparison between group 2 versus group 4, $ comparison between group 3 versus group 4. Control with HPV negative considered as the reference group. P is adjusted P-value based on the marginally adjusted 푝 values by the Benjamini-Hochberg-FDR correction at α = 0.05, Bold P-values indicated as statistically significant at 0.05 level