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Table 3 Comparison of cellular factors levels between the studied groups

From: The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue

Cellular factors

Patient with HPV + (N = 54), Group 1

Patient with HPV - (N = 48), Group 2

Control with HPV + (N = 12), Group 3

Control with HPV - (N = 36), Group 4

F.change, P*

F.change, P+

F.change, P$

P53

3.7 ± 2.01

16.02 ± 6.34

2.75 ± 1.54

15.11 ± 4.48

0.24, < 0.001

1.06, 0.677

0.18, < 0.001

Rb

2.94 ± 1.85

12.5 ± 3.68

3.0 ± 2.29

15.78 ± 4.89

0.18, < 0.001

0.79, < 0.001

0.19, < 0.001

TGF_β

18.57 ± 6.76

5.81 ± 3.27

9.33 ± 3.60

7.72 ± 3.29

2.4, 0.637

0.75, 0.189

1.2, < 0.001

IL-11

19.09 ± 6.08

5.25 ± 3.85

20.75 ± 7.34

3.78 ± 2.19

5.05, < 0.001

1.38, 0.382

5.49, < 0.001

IL-6

15.19 ± 5.30

3.88 ± 3.56

16.0 ± 6.03

4.33 ± 1.93

3.51, < 0.001

0.89, 0.931

3.69, < 0.001

IL-1

16.19 ± 5.88

4.04 ± 2.54

17.42 ± 7.26

4.44 ± 2.13

3.64, < 0.001

0.9, 0.957

3.92, < 0.001

TNF_α

12.83 ± 5.97

3.54 ± 3.33

21.5 ± 6.97

3.81 ± 1.43

3.36, < 0.001

0.93, 0.988

5.64, < 0.001

NFK_B

13.02 ± 5.89

4.15 ± 4.42

20.58 ± 6.54

4.17 ± 2.07

3.12, < 0.001

0.99, 0.99

4.93, < 0.001

IFN-Alpha

16.94 ± 7.37

2.92 ± 3.58

17.75 ± 5.31

2.67 ± 1.19

6.34, < 0.001

1.09, 0.993

6.64, < 0.001

IFN-Beta

16.09 ± 6.53

2.73 ± 2.37

16.83 ± 6.01

2.86 ± 1.39

5.62, < 0.001

0.95, 0.998

5.88, < 0.001

PTPN13

2.91 ± 1.53

19.33 ± 4.84

5.25 ± 3.52

15.66 ± 3.89

0.18, < 0.001

1.23, < 0.001

0.33, < 0.001

E-cad

3.61 ± 1.82

4.88 ± 3.55

3.42 ± 0.99

9.17 ± 6.05

0.39, < 0.001

0.53, < 0.001

0.37, < 0.001

N-cad

23.48 ± 7.09

9.83 ± 4.27

18.33 ± 7.49

13.36 ± 5.89

1.75, 0.041

0.73, 0.025

1.37, 0.001

TWIST

28.43 ± 5.0

12.54 ± 5.50

23.58 ± 5.76

10.31 ± 6.23

2.75, < 0.001

1.22, 0.171

2.28, 0.001

ROS

17.37 ± 7.57

3.65 ± 2.93

19.25 ± 6.81

3.58 ± 1.93

4.85, < 0.001

1.02, 0.99

5.38, < 0.001

RNS

19.19 ± 8.43

4.48 ± 3.07

20.58 ± 6.06

4.14 ± 1.98

4.63, < 0.001

1.08, 0.987

4.97, < 0.001

SLUG

28.33 ± 5.59

14.08 ± 5.47

20.42 ± 6.11

9.28 ± 4.94

3.05, < 0.001

1.52, < 0.001

2.2, < 0.001

  1. F. change: Fold Change, Geometric Mean ± Standard Deviation, * comparison between group 1 versus group 4, + comparison between group 2 versus group 4, $ comparison between group 3 versus group 4. Control with HPV negative considered as the reference group. P is adjusted P-value based on the marginally adjusted 푝 values by the Benjamini-Hochberg-FDR correction at α = 0.05, Bold P-values indicated as statistically significant at 0.05 level
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