Table 1 Patient characteristics
Patient characteristics | n = 43 |
|---|---|
Age at diagnosis in years, median (range) | 4.2 (1.6–17.7) |
Sex, n (%) | |
 Female | 18 (42%) |
 Male | 25 (58%) |
Immunophenotype ALL, n (%) | |
 B-lineage | 38 (88%) |
 T-lineage | 5 (12%) |
Risk group ALL-10 protocol, n (%) | |
 Standard risk | 19 (44%) |
 Medium risk | 24 (56%) |
Protocol M characteristics | |
 Duration Protocol M in days, median (range) | 65 (56–83) |
 Extra hospital admissions during protocol M, n (percentage of 172 courses) | 12 (7%) |
Duration HD-MTX hospital admission in days, median (range) | |
 After Course 1 | 2 (2–13) |
 After Course 2 | 2 (2–5) |
 After Course 3 | 2 (2–8) |
 After Course 4 | 2 (2–6) |
Toxicity during Protocol M (NCI CTC) | |
 Number of infections, n (%) | 10 (23%) |
 Number of Erythrocyte transfusions per patient, median (range) | 0 (0–3) |
 Number of Thrombocyte transfusions per patient, median (range) | 0 (0–1) |
Leukopenia, n (%) | |
 Grade 1–2 | 28 (65%) |
 Grade 3–4 | 15 (35%) |
Neutropenia, n (%) | |
 Grade 1–2 | 17 (40%) |
 Grade 3–4 | 26 (60%) |
Increased creatinine T48 | |
 Grade 1–2 | 43 (100%) |
 Grade 3–4 | 0 (0%) |
Neurotoxicity | |
 Grade 1–2 | 42 (98%) |
 Grade 3–4 | 1 (2%) |
Oral Mucositis | |
 Grade 1–2 | 28 (65%) |
 Grade 3–4 | 15 (35%) |