Fig. 4

mRNA expression of genes involved in transport and metabolism of gemcitabine in BxPC-3 (upper panel), CFPAC-1 (middle panel), and Panc-1 (lower panel). a Schematic overview of the genes encoding for the transporters (SLC29A1, SLC28A1, and SLC28A3), activating enzymes (dCK, CMPK1, and NME1), and inactivating enzymes (CDA, NT5E, and DCTD) of gemcitabine. b Percentage change in mRNA expression between untreated control cells (white bars) and after 72 h IFN-β (coloured bars). Used concentrations IFN-β: 100 IU/ml for BxPC-3 and CFPAC-1, and 1000 IU/ml for Panc-1. Values represent mean ± SEM of at least two independent experiments in quadruplicate and are shown as a percentage of control. **p < 0.01 and ***p < 0.001 versus control