|
SNP ID
|
Genotype
|
Univariate
|
Multivariate a
|
|---|
|
OS
|
PFS
|
OS
|
PFS
|
|---|
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
HR (95% CI)
|
p
|
|---|
|
Overall
|
|
rs17735387
|
GG
|
1
| |
1
| |
1
| |
1
| |
|
GA
|
0.85 (0.70–1.03)
|
0.097
|
0.83 (0.69–1.01)
|
0.059
|
0.84 (0.69–1.01)
|
0.067
|
0.82 (0.68–0.99)
|
0.042
|
|
AA
|
0.70 (0.43–1.12)
|
0.136
|
0.66 (0.41–1.07)
|
0.089
|
0.84 (0.46–1.19)
|
0.211
|
0.71 (0.44–1.14)
|
0.158
|
|
rs72640334
|
CC
|
1
| |
1
| |
1
| |
1
| |
|
CA
|
1.08 (0.86–1.36)
|
0.508
|
1.07 (0.85–1.35)
|
0.560
|
1.08 (0.85–1.37)
|
0.520
|
1.09 (0.86–1.38)
|
0.467
|
|
AA
|
1.56 (0.74–3.29)
|
0.247
|
1.44 (0.68–3.05)
|
0.335
|
1.25 (0.58–2.66)
|
0.569
|
1.20 (0.56–2.56)
|
0.633
|
|
rs7318578
|
AA
|
1
| |
1
| |
1
| |
1
| |
|
AC
|
1.07 (0.88–1.30)
|
0.493
|
1.11 (0.91–1.35)
|
0.310
|
1.07 (0.88–1.30)
|
0.516
|
1.10 (0.90–1.34)
|
0.353
|
|
CC
|
1.03 (0.82–1.30)
|
0.776
|
1.04 (0.82–1.30)
|
0.762
|
1.05 (0.83–1.32)
|
0.701
|
1.04 (0.83–1.31)
|
0.725
|
|
rs7336610
|
TT
|
1
| |
1
| |
1
| |
1
| |
|
TC
|
1.00 (0.81–0.23)
|
0.98
|
0.99 (0.81–1.23)
|
0.957
|
0.96 (0.78–1.18)
|
0.703
|
0.96 (0.78–1.18)
|
0.698
|
|
CC
|
0.93 (0.72–1.19)
|
0.549
|
0.89 (0.69–1.15)
|
0.381
|
0.91 (0.71–1.17)
|
0.480
|
0.89 (0.69–1.15)
|
0.375
|
|
rs75267932
|
AA
|
1
| |
1
| |
1
| |
1
| |
|
AG
|
1.07 (0.85–1.33)
|
0.585
|
1.07 (0.85–1.34)
|
0.568
|
1.04 (0.83–1.31)
|
0.727
|
1.05 (0.84–1.32)
|
0.671
|
|
GG
|
1.14 (0.61–2.14)
|
0.675
|
1.24 (0.66–2.32)
|
0.502
|
1.17 (0.62–2.20)
|
0.633
|
1.24 (0.66–2.34)
|
0.502
|
|
Low-grade glioma (I-II)
| | | |
|
rs17735387
|
GG
|
1
| |
1
| |
1
| |
1
| |
|
GA
|
0.77 (0.60–0.99)
|
0.042
|
0.75 (0.58–0.97)
|
0.024
|
0.75 (0.58–0.96)
|
0.024
|
0.73 (0.57–0.94)
|
0.016
|
|
AA
|
0.64 (0.36–1.15)
|
0.138
|
0.62 (0.35–1.11)
|
0.110
|
0.68 (0.38–1.22)
|
0.195
|
0.70 (0.39–1.26)
|
0.233
|
|
Females
|
|
rs72640334
|
CC
|
1
| |
1
| |
1
| | | |
|
CA
|
1.49 (1.05–2.14)
|
0.027
|
1.48 (1.03–2.12)
|
0.034
|
0.89 (0.65–1.21)
|
0.454
|
0.88 (0.65–1.20)
|
0.427
|
|
AA
|
1.50 (0.66–3.38)
|
0.332
|
1.35 (0.60–3.05)
|
0.470
|
2.05 (0.28–4.87)
|
0.477
|
2.62 (0.36–8.99)
|
0.342
|
|
Age ≥ 40 years
|
|
rs17735387
|
GG
|
1
| |
1
| |
1
| |
1
| |
|
GA
|
1.30 (1.00–1.68)
|
0.500
|
0.80 (0.62–1.04)
|
0.098
|
0.77 (0.59–1.00)
|
0.047
|
0.79 (0.61–1.03)
|
0.084
|
|
AA
|
1.00 (0.74–1.35)
|
0.993
|
0.36 (0.17–0.76)
|
0.007
|
0.46 (0.22–1.00)
|
0.049
|
0.45 (0.21–0.97)
|
0.042
|
- Abbreviations: OS Overall survival, PFS Progression free survival, HR Hazard ratio, CI Confidence interval
- a p values were calculated by Cox multivariate analysis with adjustments for gender, age, WHO grade, surgical method, use of radiotherapy and chemotherapy
- Bold p < 0.05 indicates statistical significance
