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Table 6 Cox proportional hazards model of the association between MIR17HG variants and OS and PFS of glioma patients

From: Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

SNP ID

Genotype

Univariate

Multivariate a

OS

PFS

OS

PFS

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

HR (95% CI)

p

Overall

 rs17735387

GG

1

 

1

 

1

 

1

 

GA

0.85 (0.70–1.03)

0.097

0.83 (0.69–1.01)

0.059

0.84 (0.69–1.01)

0.067

0.82 (0.68–0.99)

0.042

AA

0.70 (0.43–1.12)

0.136

0.66 (0.41–1.07)

0.089

0.84 (0.46–1.19)

0.211

0.71 (0.44–1.14)

0.158

 rs72640334

CC

1

 

1

 

1

 

1

 

CA

1.08 (0.86–1.36)

0.508

1.07 (0.85–1.35)

0.560

1.08 (0.85–1.37)

0.520

1.09 (0.86–1.38)

0.467

AA

1.56 (0.74–3.29)

0.247

1.44 (0.68–3.05)

0.335

1.25 (0.58–2.66)

0.569

1.20 (0.56–2.56)

0.633

 rs7318578

AA

1

 

1

 

1

 

1

 

AC

1.07 (0.88–1.30)

0.493

1.11 (0.91–1.35)

0.310

1.07 (0.88–1.30)

0.516

1.10 (0.90–1.34)

0.353

CC

1.03 (0.82–1.30)

0.776

1.04 (0.82–1.30)

0.762

1.05 (0.83–1.32)

0.701

1.04 (0.83–1.31)

0.725

 rs7336610

TT

1

 

1

 

1

 

1

 

TC

1.00 (0.81–0.23)

0.98

0.99 (0.81–1.23)

0.957

0.96 (0.78–1.18)

0.703

0.96 (0.78–1.18)

0.698

CC

0.93 (0.72–1.19)

0.549

0.89 (0.69–1.15)

0.381

0.91 (0.71–1.17)

0.480

0.89 (0.69–1.15)

0.375

 rs75267932

AA

1

 

1

 

1

 

1

 

AG

1.07 (0.85–1.33)

0.585

1.07 (0.85–1.34)

0.568

1.04 (0.83–1.31)

0.727

1.05 (0.84–1.32)

0.671

GG

1.14 (0.61–2.14)

0.675

1.24 (0.66–2.32)

0.502

1.17 (0.62–2.20)

0.633

1.24 (0.66–2.34)

0.502

Low-grade glioma (I-II)

   

 rs17735387

GG

1

 

1

 

1

 

1

 

GA

0.77 (0.60–0.99)

0.042

0.75 (0.58–0.97)

0.024

0.75 (0.58–0.96)

0.024

0.73 (0.57–0.94)

0.016

AA

0.64 (0.36–1.15)

0.138

0.62 (0.35–1.11)

0.110

0.68 (0.38–1.22)

0.195

0.70 (0.39–1.26)

0.233

Females

 rs72640334

CC

1

 

1

 

1

   

CA

1.49 (1.05–2.14)

0.027

1.48 (1.03–2.12)

0.034

0.89 (0.65–1.21)

0.454

0.88 (0.65–1.20)

0.427

AA

1.50 (0.66–3.38)

0.332

1.35 (0.60–3.05)

0.470

2.05 (0.28–4.87)

0.477

2.62 (0.36–8.99)

0.342

Age ≥ 40 years

 rs17735387

GG

1

 

1

 

1

 

1

 

GA

1.30 (1.00–1.68)

0.500

0.80 (0.62–1.04)

0.098

0.77 (0.59–1.00)

0.047

0.79 (0.61–1.03)

0.084

AA

1.00 (0.74–1.35)

0.993

0.36 (0.17–0.76)

0.007

0.46 (0.22–1.00)

0.049

0.45 (0.21–0.97)

0.042

  1. Abbreviations: OS Overall survival, PFS Progression free survival, HR Hazard ratio, CI Confidence interval
  2. a p values were calculated by Cox multivariate analysis with adjustments for gender, age, WHO grade, surgical method, use of radiotherapy and chemotherapy
  3. Bold p < 0.05 indicates statistical significance
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BMC Cancer

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