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Table 6 Cox proportional hazards model of the association between MIR17HG variants and OS and PFS of glioma patients

From: Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

SNP ID Genotype Univariate Multivariate a
OS PFS OS PFS
HR (95% CI) p HR (95% CI) p HR (95% CI) p HR (95% CI) p
Overall
 rs17735387 GG 1   1   1   1  
GA 0.85 (0.70–1.03) 0.097 0.83 (0.69–1.01) 0.059 0.84 (0.69–1.01) 0.067 0.82 (0.68–0.99) 0.042
AA 0.70 (0.43–1.12) 0.136 0.66 (0.41–1.07) 0.089 0.84 (0.46–1.19) 0.211 0.71 (0.44–1.14) 0.158
 rs72640334 CC 1   1   1   1  
CA 1.08 (0.86–1.36) 0.508 1.07 (0.85–1.35) 0.560 1.08 (0.85–1.37) 0.520 1.09 (0.86–1.38) 0.467
AA 1.56 (0.74–3.29) 0.247 1.44 (0.68–3.05) 0.335 1.25 (0.58–2.66) 0.569 1.20 (0.56–2.56) 0.633
 rs7318578 AA 1   1   1   1  
AC 1.07 (0.88–1.30) 0.493 1.11 (0.91–1.35) 0.310 1.07 (0.88–1.30) 0.516 1.10 (0.90–1.34) 0.353
CC 1.03 (0.82–1.30) 0.776 1.04 (0.82–1.30) 0.762 1.05 (0.83–1.32) 0.701 1.04 (0.83–1.31) 0.725
 rs7336610 TT 1   1   1   1  
TC 1.00 (0.81–0.23) 0.98 0.99 (0.81–1.23) 0.957 0.96 (0.78–1.18) 0.703 0.96 (0.78–1.18) 0.698
CC 0.93 (0.72–1.19) 0.549 0.89 (0.69–1.15) 0.381 0.91 (0.71–1.17) 0.480 0.89 (0.69–1.15) 0.375
 rs75267932 AA 1   1   1   1  
AG 1.07 (0.85–1.33) 0.585 1.07 (0.85–1.34) 0.568 1.04 (0.83–1.31) 0.727 1.05 (0.84–1.32) 0.671
GG 1.14 (0.61–2.14) 0.675 1.24 (0.66–2.32) 0.502 1.17 (0.62–2.20) 0.633 1.24 (0.66–2.34) 0.502
Low-grade glioma (I-II)    
 rs17735387 GG 1   1   1   1  
GA 0.77 (0.60–0.99) 0.042 0.75 (0.58–0.97) 0.024 0.75 (0.58–0.96) 0.024 0.73 (0.57–0.94) 0.016
AA 0.64 (0.36–1.15) 0.138 0.62 (0.35–1.11) 0.110 0.68 (0.38–1.22) 0.195 0.70 (0.39–1.26) 0.233
Females
 rs72640334 CC 1   1   1    
CA 1.49 (1.05–2.14) 0.027 1.48 (1.03–2.12) 0.034 0.89 (0.65–1.21) 0.454 0.88 (0.65–1.20) 0.427
AA 1.50 (0.66–3.38) 0.332 1.35 (0.60–3.05) 0.470 2.05 (0.28–4.87) 0.477 2.62 (0.36–8.99) 0.342
Age ≥ 40 years
 rs17735387 GG 1   1   1   1  
GA 1.30 (1.00–1.68) 0.500 0.80 (0.62–1.04) 0.098 0.77 (0.59–1.00) 0.047 0.79 (0.61–1.03) 0.084
AA 1.00 (0.74–1.35) 0.993 0.36 (0.17–0.76) 0.007 0.46 (0.22–1.00) 0.049 0.45 (0.21–0.97) 0.042
  1. Abbreviations: OS Overall survival, PFS Progression free survival, HR Hazard ratio, CI Confidence interval
  2. a p values were calculated by Cox multivariate analysis with adjustments for gender, age, WHO grade, surgical method, use of radiotherapy and chemotherapy
  3. Bold p < 0.05 indicates statistical significance