|
SNP ID
|
Allele/Genotype
|
OR (95% CI)
|
p
|
FDR-p
|
OR (95% CI)
|
p
|
FDR-p
|
|---|
|
Age (year)
| |
≥ 40
| |
< 40
| |
|
rs17735387
|
G
|
1
| | |
1
| | |
|
A
|
0.79 (0.59–1.07)
|
0.128
|
0.400
|
1.53 (1.11–2.11)
|
9.05 × 10− 3
|
0.109
|
|
GG
|
1
| | |
1
| | |
|
GA
|
0.73 (0.51–1.05)
|
0.093
|
0.465
|
1.45 (0.98–2.16)
|
0.065
|
0.142
|
|
AA
|
0.87 (0.35–2.16)
|
0.765
|
0.911
|
3.27 (1.09–9.80)
|
0.034
| |
|
GA + AA
|
0.74 (0.52–1.06)
|
0.101
|
0.421
|
1.57 (1.07–2.30)
|
0.021
|
0.101
|
|
Additive
|
0.80 (0.59–1.08)
|
0.152
|
0.380
|
1.56 (1.12–2.18)
|
8.55 × 10−3
|
0.205
|
|
rs7318578
|
A
|
1
| | |
1
| | |
|
C
|
1.27 (0.99–1.62)
|
0.063
|
0.525
|
1.37 (1.05–1.79)
|
0.020
|
0.120
|
|
AA
|
1
| | |
1
| | |
|
AC
|
0.64 (0.44–1.02)
|
0.051
|
0.188
|
0.94 (0.63–1.40)
|
0.754
|
0.952
|
|
CC
|
2.46 (1.42–4.28)
|
1.41 × 10–3*
|
0.035
|
1.88 (1.08–3.28)
|
0.026
|
0.089
|
|
AC + CC
|
0.92 (0.66–1.28)
|
0.606
|
0.947
|
1.15 (0.80–1.64)
|
0.459
|
0.648
|
|
Additive
|
1.22 (0.97–1.54)
|
0.087
|
0.544
|
1.24 (0.97–1.60)
|
0.092
|
0.170
|
|
rs7336610
|
T
|
1
| | |
1
| | |
|
C
|
1.17 (0.93–1.48)
|
0.184
|
0.418
|
1.35 (1.06–1.73)
|
0.016
|
0.128
|
|
TT
|
1
| | |
1
| | |
|
TC
|
1.35 (0.90–2.03)
|
0.144
|
0.400
|
1.56 (1.02–2.39)
|
0.041
|
0.109
|
|
CC
|
1.35 (0.84–2.16)
|
0.210
|
0.438
|
1.72 (1.02–2.92)
|
0.044
|
0.106
|
|
TC + CC
|
1.35 (0.92–1.98)
|
0.123
|
0.439
|
1.61 (1.07–2.41)
|
0.022
|
0.088
|
|
Additive
|
1.16 (0.92–1.47)
|
0.213
|
0.410
|
1.33 (1.02–1.73)
|
0.034
|
0.102
|
|
Gender
| |
Male
| | |
Female
| | |
|
rs7318578
|
A
|
1
| | |
1
| | |
|
C
|
1.18 (0.93–1.50)
|
0.183
|
0.488
|
1.53 (1.16–2.01)
|
2.49 × 10–3*
|
0.029
|
|
AA
|
1
| | |
1
| | |
|
AC
|
0.70 (0.49–1.05)
|
0.054
|
0.588
|
0.90 (0.61–1.33)
|
0.606
|
0.007
|
|
CC
|
1.80 (1.10–2.95)
|
0.020
|
0.480
|
3.08 (1.67–5.67)
|
3.19 × 10–4*
|
0.871
|
|
AC + CC
|
0.93 (0.67–1.28)
|
0.635
|
0.802
|
1.24 (0.87–1.77)
|
0.234
|
0.769
|
|
Additive
|
1.15 (0.92–1.43)
|
0.226
|
0.493
|
1.43 (1.11–1.84)
|
5.96 × 10−3
|
0.046
|
- Abbreviations: SNP Single nucleotide polymorphism, OR Odds ratio, CI Confidence interval, FDR False discovery
- p values were calculated by logistic regression analysis with adjustments for age and gender
- Bold p < 0.05 means the data is statistically significant
- * After Bonferroni correction [p < 0.05/(5 × 4)] means the data is statistically significant
