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Table 3 The effect of MIR17HG variants on the risk of glioma stratified by age and gender

From: Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

SNP ID

Allele/Genotype

OR (95% CI)

p

FDR-p

OR (95% CI)

p

FDR-p

Age (year)

 

≥ 40

 

< 40

 

rs17735387

G

1

  

1

  

A

0.79 (0.59–1.07)

0.128

0.400

1.53 (1.11–2.11)

9.05 × 10− 3

0.109

GG

1

  

1

  

GA

0.73 (0.51–1.05)

0.093

0.465

1.45 (0.98–2.16)

0.065

0.142

AA

0.87 (0.35–2.16)

0.765

0.911

3.27 (1.09–9.80)

0.034

 

GA + AA

0.74 (0.52–1.06)

0.101

0.421

1.57 (1.07–2.30)

0.021

0.101

Additive

0.80 (0.59–1.08)

0.152

0.380

1.56 (1.12–2.18)

8.55 × 10−3

0.205

rs7318578

A

1

  

1

  

C

1.27 (0.99–1.62)

0.063

0.525

1.37 (1.05–1.79)

0.020

0.120

AA

1

  

1

  

AC

0.64 (0.44–1.02)

0.051

0.188

0.94 (0.63–1.40)

0.754

0.952

CC

2.46 (1.42–4.28)

1.41 × 10–3*

0.035

1.88 (1.08–3.28)

0.026

0.089

AC + CC

0.92 (0.66–1.28)

0.606

0.947

1.15 (0.80–1.64)

0.459

0.648

Additive

1.22 (0.97–1.54)

0.087

0.544

1.24 (0.97–1.60)

0.092

0.170

rs7336610

T

1

  

1

  

C

1.17 (0.93–1.48)

0.184

0.418

1.35 (1.06–1.73)

0.016

0.128

TT

1

  

1

  

TC

1.35 (0.90–2.03)

0.144

0.400

1.56 (1.02–2.39)

0.041

0.109

CC

1.35 (0.84–2.16)

0.210

0.438

1.72 (1.02–2.92)

0.044

0.106

TC + CC

1.35 (0.92–1.98)

0.123

0.439

1.61 (1.07–2.41)

0.022

0.088

Additive

1.16 (0.92–1.47)

0.213

0.410

1.33 (1.02–1.73)

0.034

0.102

Gender

 

Male

  

Female

  

rs7318578

A

1

  

1

  

C

1.18 (0.93–1.50)

0.183

0.488

1.53 (1.16–2.01)

2.49 × 10–3*

0.029

AA

1

  

1

  

AC

0.70 (0.49–1.05)

0.054

0.588

0.90 (0.61–1.33)

0.606

0.007

CC

1.80 (1.10–2.95)

0.020

0.480

3.08 (1.67–5.67)

3.19 × 10–4*

0.871

AC + CC

0.93 (0.67–1.28)

0.635

0.802

1.24 (0.87–1.77)

0.234

0.769

Additive

1.15 (0.92–1.43)

0.226

0.493

1.43 (1.11–1.84)

5.96 × 10−3

0.046

  1. Abbreviations: SNP Single nucleotide polymorphism, OR Odds ratio, CI Confidence interval, FDR False discovery
  2. p values were calculated by logistic regression analysis with adjustments for age and gender
  3. Bold p < 0.05 means the data is statistically significant
  4. * After Bonferroni correction [p < 0.05/(5 × 4)] means the data is statistically significant
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BMC Cancer

ISSN: 1471-2407

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