Skip to main content

Table 3 The effect of MIR17HG variants on the risk of glioma stratified by age and gender

From: Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

SNP ID Allele/Genotype OR (95% CI) p FDR-p OR (95% CI) p FDR-p
Age (year)   ≥ 40   < 40  
rs17735387 G 1    1   
A 0.79 (0.59–1.07) 0.128 0.400 1.53 (1.11–2.11) 9.05 × 10− 3 0.109
GG 1    1   
GA 0.73 (0.51–1.05) 0.093 0.465 1.45 (0.98–2.16) 0.065 0.142
AA 0.87 (0.35–2.16) 0.765 0.911 3.27 (1.09–9.80) 0.034  
GA + AA 0.74 (0.52–1.06) 0.101 0.421 1.57 (1.07–2.30) 0.021 0.101
Additive 0.80 (0.59–1.08) 0.152 0.380 1.56 (1.12–2.18) 8.55 × 10−3 0.205
rs7318578 A 1    1   
C 1.27 (0.99–1.62) 0.063 0.525 1.37 (1.05–1.79) 0.020 0.120
AA 1    1   
AC 0.64 (0.44–1.02) 0.051 0.188 0.94 (0.63–1.40) 0.754 0.952
CC 2.46 (1.42–4.28) 1.41 × 10–3* 0.035 1.88 (1.08–3.28) 0.026 0.089
AC + CC 0.92 (0.66–1.28) 0.606 0.947 1.15 (0.80–1.64) 0.459 0.648
Additive 1.22 (0.97–1.54) 0.087 0.544 1.24 (0.97–1.60) 0.092 0.170
rs7336610 T 1    1   
C 1.17 (0.93–1.48) 0.184 0.418 1.35 (1.06–1.73) 0.016 0.128
TT 1    1   
TC 1.35 (0.90–2.03) 0.144 0.400 1.56 (1.02–2.39) 0.041 0.109
CC 1.35 (0.84–2.16) 0.210 0.438 1.72 (1.02–2.92) 0.044 0.106
TC + CC 1.35 (0.92–1.98) 0.123 0.439 1.61 (1.07–2.41) 0.022 0.088
Additive 1.16 (0.92–1.47) 0.213 0.410 1.33 (1.02–1.73) 0.034 0.102
Gender   Male    Female   
rs7318578 A 1    1   
C 1.18 (0.93–1.50) 0.183 0.488 1.53 (1.16–2.01) 2.49 × 10–3* 0.029
AA 1    1   
AC 0.70 (0.49–1.05) 0.054 0.588 0.90 (0.61–1.33) 0.606 0.007
CC 1.80 (1.10–2.95) 0.020 0.480 3.08 (1.67–5.67) 3.19 × 10–4* 0.871
AC + CC 0.93 (0.67–1.28) 0.635 0.802 1.24 (0.87–1.77) 0.234 0.769
Additive 1.15 (0.92–1.43) 0.226 0.493 1.43 (1.11–1.84) 5.96 × 10−3 0.046
  1. Abbreviations: SNP Single nucleotide polymorphism, OR Odds ratio, CI Confidence interval, FDR False discovery
  2. p values were calculated by logistic regression analysis with adjustments for age and gender
  3. Bold p < 0.05 means the data is statistically significant
  4. * After Bonferroni correction [p < 0.05/(5 × 4)] means the data is statistically significant