Genetic variants in MIR17HG affect the susceptibility and prognosis of glioma in a Chinese Han population

BMC Cancer

Table 2 The effect of MIR17HG variants on the risk of glioma

SNP ID	Allele/Genotype	Control	Case	OR (95% CI)	p	FDR-p
rs17735387	G	829	964	1
	A	175	220	1.08 (0.87–1.35)	0.486	0.778
	GG	341	395	1
	GA	147	174	1.02 (0.79–1.33)	0.871	0.909
	AA	14	23	1.42 (0.72–2.80)	0.315	0.756
	GA + AA	161	197	1.06 (0.82–1.36)	0.672	0.806
	Additive	/	/	1.08 (0.87–1.34)	0.488	0.732
rs72640334	C	916	1070	1
	A	86	110	1.10 (0.81–1.47)	0.547	0.772
	CC	418	487	1
	CA	80	96	1.03 (0.74–1.43)	0.860	0.938
	AA	3	7	2.01 (0.51–7.83)	0.316	0.689
	CA + AA	83	103	1.07 (0.78–1.46)	0.696	0.795
	Additive	/	/	1.09 (0.82–1.47)	0.550	0.733
rs7318578	A	714	768	1
	C	290	412	1.32 (1.10–1.58)	2.63 × 10⁻³	0.032
	AA	257	294	1
	AC	200	180	0.79 (0.61–1.02)	0.073	0.438
	CC	45	116	2.25 (1.54–3.31)	3.18 × 10^–5*	0.001
	AC + CC	245	296	1.06 (0.83–1.34)	0.654	0.826
	Additive	/	/	1.26 (1.07–1.49)	6.23 × 10⁻³	0.050
rs7336610	T	527	602	1
	C	475	580	1.07 (0.90–1.27)	0.438	0.809
	TT	141	144	1
	TC	245	314	1.26 (0.94–1.67)	0.119	0.476
	CC	115	133	1.13 (0.80–1.59)	0.477	0.818
	TC + CC	360	447	1.22 (0.93–1.59)	0.157	0.419
	Additive	/	/	1.07 (0.90–1.27)	0.433	0.866
rs75267932	A	879	1061	1
	G	125	123	0.82 (0.63–1.06)	0.130	0.446
	AA	385	479	1
	AG	109	103	0.76 (0.56–1.03)	0.073	0.438
	GG	8	10	1.01 (0.39–2.58)	0.988	0.988
	AG + GG	117	113	0.78 (0.58–1.04)	0.089	0.427
	Additive	/	/	0.82 (0.63–1.07)	0.138	0.414

Abbreviations: SNP Single nucleotide polymorphism, OR Odds ratio, CI Confidence interval, FDR False discovery
p values were calculated by logistic regression analysis with adjustments for age and gender
Bold p < 0.05 means the data is statistically significant
* After Bonferroni correction [p < 0.05/(5 × 4)] means the data is statistically significant

ISSN: 1471-2407