All | Q1 | Q2 | Q3 | Q4 | Q5 | ||
---|---|---|---|---|---|---|---|
(hyper-methylated) | (hypo-methylated) | ||||||
Quintile range | 34–98 | 84–98 | 73–84 | 64–73 | 56–64 | 34–56 | |
Lung cancer casesa | |||||||
(n = 316) | (n = 59) | (n = 78) | (n = 59) | (n = 49) | (n = 71) | P-trendb | |
cg05575921, % methylation; mean (SD) | 69.1 (14.6) | 89.6 (3.8) | 78.0 (3.1) | 68.2 (2.7) | 60.0 (2.4) | 49.2 (5.0) | – |
Age at blood draw, years; mean (SD) | 64.5 (5.5) | 65.9 (5.8) | 65.5 (5.5) | 64.9 (5.7) | 63.8 (4.9) | 62.5 (5.3) | 7 × 10−5 |
Current smoker; No. (%) | 205 (65) | 14 (24) | 38 (49) | 44 (75) | 45 (92) | 64 (90) | 2 × 10−22 |
Years since smoking cessationc; mean (SD) | 6.6 (4.8) | 8.1 (5.2) | 6.4 (4.6) | 4.3 (3.9) | 5.0 (2.2) | 3.7 (2.6) | 0.002 |
Pack years; mean (SD) | 59.3 (22.5) | 55.3 (18.4) | 59.0 (25.1) | 60.2 (22.3) | 60.7 (23.8) | 61.3 (22.2) | 0.15 |
Average cigarettes per dayd; mean (SD) | 23.3 (12.4) | 17.6 (11.6) | 17.1 (11.6) | 23.7 (12.1) | 25.4 (13.1) | 26.4 (11.4) | 8 × 10−5 |
Total years smoked; mean (SD) | 44.3 (6.7) | 42.1 (8.0) | 44.2 (6.9) | 45.5 (6.2) | 45.3 (6.0) | 44.7 (5.8) | 0.03 |
BMIe, kg/m2; mean (SD) | 27.6 (4.9) | 29.2 (4.8) | 27.6 (4.7) | 27.6 (4.7) | 27.7 (5.8) | 26.3 (4.4) | 0.004 |
Race, white; No. (%) | 307 (97) | 58 (98) | 73 (94) | 59 (100) | 47 (96) | 70 (99) | 0.56f |
Sex, female; No. (%) | 109 (34) | 21 (36) | 25 (32) | 26 (44) | 15 (31) | 22 (31) | 0.60 |
Intervention arm, assigned to active; No. (%) | 164 (52) | 30 (51) | 41 (53) | 31 (53) | 29 (59) | 33 (46) | 0.79 |
Asbestos exposure; No. (%) | 51 (16) | 15 (25) | 14 (18) | 7 (12) | 5 (10) | 10 (14) | 0.05 |
Stage; No. (%) | 0.66g | ||||||
Early stage (I/II) | 72 (23) | 13 (18) | 21 (29) | 8 (11) | 10 (14) | 20 (28) | |
Late stage (III/IV) | 195 (62) | 38 (19) | 44 (23) | 42 (22) | 31 (16) | 40 (21) | |
Unknown stage | 49 (16) | 8 (16) | 13 (27) | 9 (18) | 8 (16) | 11 (22) | |
Histotype; No. (%) | |||||||
Adenocarcinoma | 132 (42) | 28 (47) | 35 (45) | 20 (34) | 18 (37) | 31 (44) | |
Squamous cell carcinoma | 103 (33) | 15 (25) | 23 (29) | 16 (27) | 20 (41) | 29 (41) | |
Small cell carcinoma | 71 (22) | 15 (25) | 19 (24) | 19 (32) | 9 (18) | 9 (13) | |
Any death (through 2015); No. (%) | 304 (96) | 58 (98) | 73 (94) | 56 (95) | 49 (100) | 68 (96) | 0.92f |
Years between blood draw and diagnosis; mean (SD) | 4.3 (2.5) | 3.6 (2.5) | 4.3 (2.5) | 4.5 (2.4) | 4.4 (2.6) | 4.8 (2.3) | 0.02 |
Controls | |||||||
(n = 316) | (n = 63) | (n = 64) | (n = 63) | (n = 63) | (n = 63) | P-trendb | |
cg05575921, % methylation; mean (SD) | 69.3 (14.8) | 90.8 (4.0) | 78.3 (2.9) | 67.6 (2.6) | 60.0 (2.0) | 49.4 (5.0) | – |
Age at blood draw, years; mean (SD) | 63.5 (5.7) | 64.6 (6.0) | 63.6 (5.2) | 64.2 (5.8) | 61.7 (5.9) | 63.4 (5.4) | 0.07 |
Current smoker; No. (%) | 205 (65) | 14 (22) | 28 (44) | 49 (78) | 58 (92) | 56 (89) | 4 × 10−25 |
Years since smoking cessationc; mean (SD) | 6.6 (6.4) | 9.0 (7.9) | 5.6 (4.3) | 4.1 (3.4) | 2.8 (2.6) | 3.9 (4.5) | 0.001 |
Pack years; mean (SD) | 54.2 (24.1) | 48.4 (23.5) | 53.6 (18.8) | 52.9 (23.2) | 53.7 (25.8) | 62.2 (27.2) | 0.004 |
Average cigarettes per dayd; mean (SD) | 21.5 (10.7) | 20.9 (8.6) | 19.1 (10.9) | 21.2 (9.7) | 19.7 (9.9) | 25.0 (11.9) | 0.04 |
Total years smoked; mean (SD) | 42.5 (7.4) | 38.6 (8.0) | 41.0 (6.9) | 43.8 (6.9) | 43.2 (7.3) | 45.8 (6.0) | 1 × 10−8 |
BMIe, kg/m2; mean (SD) | 28.1 (5.5) | 29.2 (5.0) | 29.3 (6.9) | 27.6 (5.4) | 27.7 (5.4) | 26.6 (4.3) | 0.002 |
Race, white; No. (%) | 307 (97) | 62 (98) | 59 (92) | 61 (97) | 62 (98) | 63 (100) | 0.19f |
Sex, female; No. (%) | 109 (34) | 27 (43) | 20 (31) | 21 (33) | 24 (38) | 17 (27) | 0.19 |
Intervention arm, assigned to active; No. (%) | 168 (53) | 27 (43) | 32 (50) | 36 (57) | 38 (60) | 35 (56) | 0.07 |
Asbestos exposure; No. (%) | 51 (16) | 18 (29) | 12 (19) | 5 (8) | 12 (19) | 4 (6) | 0.003 |
Any death (through 2015); No. (%) | 187 (59) | 33 (52) | 33 (52) | 40 (63) | 41 (65) | 40 (63) | 0.07 |