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Fig. 6 | BMC Cancer

Fig. 6

From: Chemotherapy-induced release of circulating-tumor cells into the bloodstream in collective migration units with cancer-associated fibroblasts in metastatic cancer patients

Fig. 6

Minimal reduction of CTC viability by chemotherapy and soluble TRAIL. a Bar graphs display the viable CTC percentage in treated samples with PBS and chemotherapeutic agents (Docetaxel-DXT, 5-Fluorouracil-5-FU, Oxaliplatin-OXA, Paclitaxel-PTX) in Met-pa (mean ± SD, N = 24 from 10 patients at different time points of chemotherapy treatment). Significant reduction in (*P = 0.0317) in CTC viability due to the chemotherapy was determined using a paired t test. b Bar graphs represent the CTC viability percentage in samples treated with PBS and soluble TRAIL (mean ± SD, N = 12, from 6 patients). Significant reduction in CTC viability percentage (**P = 0.0048) by soluble TRAIL was calculated using a paired t test. c Immunofluorescence photomicrographs of viable cells obtained from breast, prostate and colorectal cancer patients after ex vivo treatment with chemotherapies, including docetaxel, paclitaxel, and soluble TRAIL (CD45 is red, cytokeratin is green and DAPI is blue). Scale bar is 40 μm

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BMC Cancer

ISSN: 1471-2407

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