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Fig. 1 | BMC Cancer

Fig. 1

From: Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth

Fig. 1

Elevating SOX2 reversibly inhibits i-SOX2-T3M4 tumor growth in vivo. a Subcutaneous i-SOX2-T3M4 tumor growth of control and Dox-treated mice. Dox treatment was started and ended at the days indicated. Average tumor volumes are presented for control and Dox-treated groups. b IHC analysis of SOX2 expression (percent of cells) in a control tumor, a Dox-growth inhibited tumor, and a Dox-withdrawn tumor. c IHC analysis of CC3 in a control and a Dox-treated tumor. d Subcutaneous parental T3M4 tumor growth of control and Dox-treated mice. Dox treatment was started and ended at the days indicated. Average tumor volumes are presented for control and Dox-treated groups. Error bars represent standard error of the mean; statistical significance was determined by two-tailed student’s t-test (*p < 0.05, ***p < 0.005)

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BMC Cancer

ISSN: 1471-2407

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