The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis

Table 2 Subgroup analyses concerning the impact of TERT promoter mutation and MGMT methylation on overall survival of LGGs and GBMs

Subgroups			HR	95% CI	p-value	I²(%)
LGG	TERT-mut vs TERT-wt	MGMT-met	0.62	0.31–1.24	0.180	60
LGG		MGMT-unmet	1.47	1.01–2.16	0.045	0
GBM		MGMT-met	0.79	0.59–1.05	0.110	17
GBM		MGMT-unmet	1.93	1.55–2.41	< 0.001	0
LGG	MGMT-met vs MGMT-unmet	TERT-mut	0.26	0.11–0.63	0.003	65
LGG		TERT-wt	0.41	0.26–0.64	< 0.001	0
GBM		TERT-mut	0.31	0.25–0.39	< 0.001	0
GBM		TERT-wt	0.85	0.67–1.07	0.160	0

Abbreviations: CI Confidence interval, met Methylated, GBM Glioblastoma, HR Hazard ratio, LGG Lower-grade glioma, mut Mutated, unmet Unmethylated, wt Wild-type

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