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Table 2 Subgroup analyses concerning the impact of TERT promoter mutation and MGMT methylation on overall survival of LGGs and GBMs

From: The interaction between TERT promoter mutation and MGMT promoter methylation on overall survival of glioma patients: a meta-analysis

Subgroups HR 95% CI p-value I2(%)
LGG TERT-mut vs TERT-wt MGMT-met 0.62 0.31–1.24 0.180 60
MGMT-unmet 1.47 1.01–2.16 0.045 0
GBM MGMT-met 0.79 0.59–1.05 0.110 17
MGMT-unmet 1.93 1.55–2.41 < 0.001 0
LGG MGMT-met vs MGMT-unmet TERT-mut 0.26 0.11–0.63 0.003 65
TERT-wt 0.41 0.26–0.64 < 0.001 0
GBM TERT-mut 0.31 0.25–0.39 < 0.001 0
TERT-wt 0.85 0.67–1.07 0.160 0
  1. Abbreviations: CI Confidence interval, met Methylated, GBM Glioblastoma, HR Hazard ratio, LGG Lower-grade glioma, mut Mutated, unmet Unmethylated, wt Wild-type