Table 5 Multivariable regression odds ratios for receiving chemotherapy stratified by low and intermediate ODX RS

 2010

Ref

Ref

Ref

Ref

 2011

0.68 (0.21–2.17)

0.50

1.17 (0.45–3.04)

0.75

 2012

0.48 (0.14–1.72)

0.25

2.23 (0.82–6.06)

0.11

 2013

0.34 (0.10–1.17)

0.08

1.10 (0.41–2.95)

0.84

 2014

0.40 (0.12–1.39)

0.14

0.67 (0.26–1.72)

0.40

 2015

0.21 (0.05–0.86)

0.03*

1.07 (0.41–2.76)

0.89

 2016

0.25 (0.06–0.94)

0.04*

1.10 (0.39–3.10)

0.85

 < 50

Ref

Ref

Ref

Ref

 50–59

0.67 (0.30–1.50)

0.32

0.59 (0.31–1.13)

0.11

 60–69

0.17 (0.06–0.49)

< 0.01**

0.29 (0.14–0.59)

< 0.01**

 > 69

0.08 (0.02–0.45)

< 0.01**

0.10 (0.03–0.33)

< 0.01**

 I

Ref

Ref

Ref

Ref

 II

1.48 (0.58–3.73)

0.40

2.00 (1.06–3.80)

0.03*

 III/IV

7.80 (2.62–23.27)

< 0.01**

2.37 (1.10–5.11)

0.02*

 Unknown

0.00 (0.00-Inf)

0.99

0.00 (0.00-Inf)

0.99

 Negative

Ref

Ref

Ref

Ref

 Positive

5.84 (2.61–13.05)

< 0.01**

1.93 (0.92–4.05)

0.08

 Unknown

2.91 (0.25–34.27)

0.38

0.50 (0.04–6.96)

0.60

 0.1–19

Ref

Ref

Ref

Ref

 20–39

0.96 (0.38–2.41)

0.93

1.26 (0.55–2.88)

0.58

 > 40

8.16 (2.37–28.06)

< 0.01**

0.94 (0.19–4.62)

0.94

 Unknown

0.00 (0.00-Inf)

0.99

0.79 (0.07–9.12)

0.85

 1

Ref

Ref

Ref

Ref

 2

2.96 (1.10–7.98)

0.03*

2.59 (1.04–6.47)

0.04*

 3 / 4

6.22 (1.18–32.74)

0.03*

0.36 (0.01–9.58)

0.53

 < 10

Ref

Ref

Ref

Ref

 10–19

2.56 (0.26–25.28)

0.41

0.75 (0.21–2.64)

0.65

 20–29

4.31 (0.44–41.94)

0.20

1.61 (0.44–5.88)

0.46

 > 29

7.71 (0.75–79.43)

0.08

2.02 (0.55–7.48)

0.28

 Female

Ref

Ref

Ref

Ref

 Male

0.39 (0.17–0.88)

0.02*

0.73 (0.42–1.27)

0.26

Patient Volume

0.98 (0.95–1.00)

0.08

1.01 (0.99–1.02)

0.40

 < 65 Years

Ref

Ref

Ref

Ref

 > 65 Years

0.59 (0.13–2.74)

0.50

0.76 (0.23–2.53)

0.65

ODX RS

0.98 (0.96–1.00)

0.15

1.33 (1.22–1.44)

< 0.01**