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Table 5 Multivariable regression odds ratios for receiving chemotherapy stratified by low and intermediate ODX RS

From: Patient and physician factors associated with Oncotype DX and adjuvant chemotherapy utilization for breast cancer patients in New Hampshire, 2010–2016

Variable Odds Ratio (95% CI)
Low RS
P-Value Odds Ratio (95% CI) Intermediate RS P-Value
Year of Diagnosis
 2010 Ref Ref Ref Ref
 2011 0.68 (0.21–2.17) 0.50 1.17 (0.45–3.04) 0.75
 2012 0.48 (0.14–1.72) 0.25 2.23 (0.82–6.06) 0.11
 2013 0.34 (0.10–1.17) 0.08 1.10 (0.41–2.95) 0.84
 2014 0.40 (0.12–1.39) 0.14 0.67 (0.26–1.72) 0.40
 2015 0.21 (0.05–0.86) 0.03* 1.07 (0.41–2.76) 0.89
 2016 0.25 (0.06–0.94) 0.04* 1.10 (0.39–3.10) 0.85
Patient Age at Diagnosis (Years)
 < 50 Ref Ref Ref Ref
 50–59 0.67 (0.30–1.50) 0.32 0.59 (0.31–1.13) 0.11
 60–69 0.17 (0.06–0.49) < 0.01** 0.29 (0.14–0.59) < 0.01**
 > 69 0.08 (0.02–0.45) < 0.01** 0.10 (0.03–0.33) < 0.01**
Grade
 I Ref Ref Ref Ref
 II 1.48 (0.58–3.73) 0.40 2.00 (1.06–3.80) 0.03*
 III/IV 7.80 (2.62–23.27) < 0.01** 2.37 (1.10–5.11) 0.02*
 Unknown 0.00 (0.00-Inf) 0.99 0.00 (0.00-Inf) 0.99
LN Status
 Negative Ref Ref Ref Ref
 Positive 5.84 (2.61–13.05) < 0.01** 1.93 (0.92–4.05) 0.08
 Unknown 2.91 (0.25–34.27) 0.38 0.50 (0.04–6.96) 0.60
Tumor Size (mm)
 0.1–19 Ref Ref Ref Ref
 20–39 0.96 (0.38–2.41) 0.93 1.26 (0.55–2.88) 0.58
 > 40 8.16 (2.37–28.06) < 0.01** 0.94 (0.19–4.62) 0.94
 Unknown 0.00 (0.00-Inf) 0.99 0.79 (0.07–9.12) 0.85
Clinical Stage
 1 Ref Ref Ref Ref
 2 2.96 (1.10–7.98) 0.03* 2.59 (1.04–6.47) 0.04*
 3 / 4 6.22 (1.18–32.74) 0.03* 0.36 (0.01–9.58) 0.53
MD Clinical Experience (Years)
 < 10 Ref Ref Ref Ref
 10–19 2.56 (0.26–25.28) 0.41 0.75 (0.21–2.64) 0.65
 20–29 4.31 (0.44–41.94) 0.20 1.61 (0.44–5.88) 0.46
 > 29 7.71 (0.75–79.43) 0.08 2.02 (0.55–7.48) 0.28
MD Gender
 Female Ref Ref Ref Ref
 Male 0.39 (0.17–0.88) 0.02* 0.73 (0.42–1.27) 0.26
Patient Volume 0.98 (0.95–1.00) 0.08 1.01 (0.99–1.02) 0.40
Average Patient Age
 < 65 Years Ref Ref Ref Ref
 > 65 Years 0.59 (0.13–2.74) 0.50 0.76 (0.23–2.53) 0.65
ODX RS 0.98 (0.96–1.00) 0.15 1.33 (1.22–1.44) < 0.01**
  1. * significant at the 0.05 level
  2. ** significant at the 0.01 level