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Table 3 Multivariable regression odds ratios for receiving ODX

From: Patient and physician factors associated with Oncotype DX and adjuvant chemotherapy utilization for breast cancer patients in New Hampshire, 2010–2016

Variable Odds Ratio (95% CI) P-Value
Year of Diagnosis
 2010 Ref Ref
 2011 1.00 (0.76–1.31) 0.99
 2012 1.00 (0.76–1.31) 0.99
 2013 1.00 (0.76–1.31) 0.98
 2014 1.05 (0.80–1.36) 0.73
 2015 1.05 (0.80–1.36) 0.73
 2016 1.09 (0.83–1.43) 0.54
Patient Age at Diagnosis (Years)
 < 50 Ref Ref
 50–59 1.04 (0.86–1.27) 0.66
 60–69 0.97 (0.79–1.18) 0.75
 > 69 0.45 (0.35–0.58) < 0.01**
Marital Status
 Single, Divorced, Widowed Ref Ref
 Married 1.22 (1.05–1.41) < 0.01**
 Unknown 1.12 (0.73–1.73) 0.59
Grade
 I Ref Ref
 II 1.22 (1.03–1.43) 0.02*
 III/IV 0.43 (0.35–0.53) < 0.01**
 Unknown 0.16 (0.06–0.42) < 0.01**
LN Status
 Negative Ref Ref
 Positive 0.70 (0.58–0.86) < 0.01**
 Unknown 0.21 (0.14–0.31) < 0.01**
Tumor Size (mm)
 0.1–19 Ref Ref
 20–39 1.69 (1.35–2.12) < 0.01**
 > 40 0.88 (0.61–1.27) 0.48
 Unknown 0.92 (0.39–2.13) 0.84
Clinical Stage
 1 Ref Ref
 2 0.80 (0.63–1.03) 0.08
 3 / 4 0.10 (0.06–0.17) < 0.01**
MD Clinical Experience (Years)
 < 10 Ref Ref
 10–19 0.89 (0.61–1.29) 0.53
 20–29 1.05 (0.71–1.57) 0.79
 > 29 1.07 (0.70–1.61) 0.76
MD Gender
 Female Ref Ref
 Male 0.98 (0.79–1.22) 0.88
Patient Volume 1.00 (0.99–1.01) 0.48
Average Patient Age
 < 65 Years Ref Ref
 > 65 Years 0.71 (0.49–1.03) 0.06
Surgical Specialty
 General Surgeon Ref Ref
 Surgical Oncologist 0.86 (0.70–1.06) 0.15
  1. * significant at the 0.05 level
  2. ** significant at the 0.01 level