Table 2 Clinico-pathologic characteristics of BRCA mutation carriers
ID | Variant | Age (Interval) | Family History | Bilateral cancer | Stage | Histology | mSBR grade | Molecular subtype |
|---|---|---|---|---|---|---|---|---|
1 | BRCA1 c.116G > A + BRCA2 c.4090A > G | 28–35 | Aunt M, lung Aunt P, liver | No | Early | NST | 3 | TN |
2 | BRCA1 c.2125_2126insA | 28–35 | P cousin, BC | No | Early | NST | 2 | TN |
3 | BRCA1 c.798_799del | 28–35 | No | No | Early | NST | 3 | TN |
4 | BRCA2 c.5116_5119delAATA | 36–40 | M cousin, uterus | Yes | Early | NST | 3 | Luminal |
5 | BRCA2 c.289G > T | 28–35 | P aunt, BC P Aunt, Arm | No | LA | NST | 2 | Luminal |
6 | BRCA2 c.6322C > T | 36–40 | P cousin, unknown | No | Early | NST | 2 | Luminal |