Table 2 Diagnostic performance of pleural and plasma pro-cathepsin D in predicting malignant pleural effusion
Pleural fluid pro-cathepsin D, pg/mL | ||||||
Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | LR+ (95% CI) | LR- (95% CI) | |
≥ 0.535 | 95.2 (74.1–99.7) | 31.7 (20.6–45.1) | 32.8 (21.6–46.1) | 95.0 (73.1–99.7) | 1.39 (1.14–1.69) | 0.15 (0.02–1.09) |
≥ 0.614 | 71.4 (47.7–87.8) | 55.0 (41.7–67.7) | 35.7 (21.9–51.0) | 84.6 (68.8–93.6) | 1.59 (1.08–2.34) | 0.52 (0.26–1.05) |
≥ 0.703 | 28.6 (12.2–52.3) | 75.0 (61.9–84.9) | 35.7 (21.9–51.0) | 28.6 (12.2–52.3) | 1.14 (0,51–2.56) | 0.95 (0.72–1.26) |
Suggested optimal cut-off, pg/mL | ||||||
0.596 | 81.0 (57.4–93.7) | 53.3 (40.1–84.9) | 37.8 (24.2–53.5) | 88.9 (72.9–96.4) | 1.73 (1.23–2.44) | 0.36 (0.14–0.89) |
Plasma pro-cathepsin D, pg/mL | ||||||
Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | LR+ (95% CI) | LR- (95% CI) | |
≥ 0.417 | 80.9 (57.4–93.7) | 26.7 (16.5–39.9) | 27.9 (17.5–41.0) | 80.0 (55.7–93.4) | 1.10 (0.85–1.43) | 0.71 (0.27–1.89) |
≥ 0.456 | 57.1 (34.4–77.4) | 50.0 (36.9–63.0) | 28.6 (16.2–44.8) | 76.9 (60.3–88.3) | 1.14 (0.73–1.79) | 0.86 (0.51–1.45) |
≥ 0.552 | 28.6 (12.2–52.3) | 72.0 (57.3–83.3) | 30.0 (12.8–54.3) | 70.0 (45.7–87.1) | 1.02 (0.45–2.29) | 0.99 (0.75–1.32) |
Suggested optimal cut-off, pg/mL | ||||||
0.465 | 57.1 (34.3–77.4) | 58.3 (44.9–70.7) | 32.4 (18.6–49.9) | 79.5 (64.2–89.7) | 1.37 (0.85–2.29) | 0.73 (0.44–1.23) |