Fig. 8

Expression of miRNA-146a is associated with downregulation of THRB in endometrial cancer. a The volcano plot shows the log₂ fold change in mean miRNA expression along the x axis between tumors that maintain versus tumors that lose THRB expression. The –log₁₀(q-value) is shown along the y axis. Each dot represents a miRNA (N = 1619). The expression of miRNAs toward the upper left of the plot is increased in endometrial tumors that lose THRB expression. b The RNA expression of miRNA-146a, in log₂(Transcripts per million reads + 1), is shown in endometrial tumors that lose and maintain THRB expression, as well as in adjacent normal endometrial tissue