Fig. 6

Loss of THRB expression associates with high-impact RNF43 and NSD1 mutations. a The steps involved for integrating TCGA data to determine the interactions between high-impact oncogenic mutations and NHR loss of expression. b High impact cancer-associated mutations are shown as rows, and each column corresponds to a NHR. The mutation frequency of each cancer-related mutation is shown in the bar graph on the right. Each entry in the heatmap corresponds to the odds ratio, with purple corresponding to positive associations between mutation and high expression, and red corresponding to negative associations between mutation and high expression. Asterisks within cells correspond to statistically significant odds ratios calculated using Fisher’s exact test and adjusted using the Benjamini-Hochberg method at the following thresholds: * = q < 0.01, ** = q < 0.001, *** = q < 0.0001