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Table 2 Univariate and multivariate Cox analysis for overall survival (n = 1177)

From: Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma

 

Univariate

Multivariate

HR

95% CI

p - value

HR

95% CI

p - value

Age > 65

1.482

1.266–1.734

< 0.001

1.476

1.245–1.750

< 0.001

Sex (male)

1.178

1.008–1.377

0.039

1.097

0.926–1.299

0.284

ECOG PS ≥ 2

1.648

1.385–1.961

< 0.001

1.495

1.240–1.802

< 0.001

Hb < 10.0 g/dL

1.271

1.086–1.488

0.003

1.030

0.852–1.244

0.763

Calcium ≥10.2 mg/dL

1.372

1.117–1.686

0.003

1.124

0.896–1.409

0.312

Diagnosis at 2009–2014a

0.638

0.386–1.054

0.079

   

Diagnosis at 2015–2017a

0.641

0.388–1.062

0.084

   

Log2 EASIX > 1.87

1.878

1.600–2.205

< 0.001

1.444

1.170–1.780

0.001

ISS 2b

1.361

1.527–2.300

< 0.001

1.226

0.966–1.557

0.094

ISS 3b

1.874

1.101–1.682

< 0.001

1.309

1.000–1.714

0.050

High-risk CA

1.838

1.469–2.300

< 0.001

1.565

1.241–1.973

< 0.001

  1. Abbreviations: ECOG PS Eastern Cooperative Oncology Group Performance Status, Hb Hemoglobin, EASIX Endothelial Activation and Stress Index, ISS International Staging System, R-ISS Revised-International Staging, System, CA Chromosomal abnormality
  2. a Diagnosis at 2003–2008 is the reference
  3. bISS 1 is the reference
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BMC Cancer

ISSN: 1471-2407

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