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Table 2 Univariate and multivariate Cox analysis for overall survival (n = 1177)

From: Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma

  Univariate Multivariate
HR 95% CI p - value HR 95% CI p - value
Age > 65 1.482 1.266–1.734 < 0.001 1.476 1.245–1.750 < 0.001
Sex (male) 1.178 1.008–1.377 0.039 1.097 0.926–1.299 0.284
ECOG PS ≥ 2 1.648 1.385–1.961 < 0.001 1.495 1.240–1.802 < 0.001
Hb < 10.0 g/dL 1.271 1.086–1.488 0.003 1.030 0.852–1.244 0.763
Calcium ≥10.2 mg/dL 1.372 1.117–1.686 0.003 1.124 0.896–1.409 0.312
Diagnosis at 2009–2014a 0.638 0.386–1.054 0.079    
Diagnosis at 2015–2017a 0.641 0.388–1.062 0.084    
Log2 EASIX > 1.87 1.878 1.600–2.205 < 0.001 1.444 1.170–1.780 0.001
ISS 2b 1.361 1.527–2.300 < 0.001 1.226 0.966–1.557 0.094
ISS 3b 1.874 1.101–1.682 < 0.001 1.309 1.000–1.714 0.050
High-risk CA 1.838 1.469–2.300 < 0.001 1.565 1.241–1.973 < 0.001
  1. Abbreviations: ECOG PS Eastern Cooperative Oncology Group Performance Status, Hb Hemoglobin, EASIX Endothelial Activation and Stress Index, ISS International Staging System, R-ISS Revised-International Staging, System, CA Chromosomal abnormality
  2. a Diagnosis at 2003–2008 is the reference
  3. bISS 1 is the reference