Table 7 The top significant changes in GO-BP (A), −CC (B), −MF(C) and KEGG pathway (D) according to differentially expressed genes in LINC00261-ceRNA sub-network

 GO-BP Term

Enrichment Score

Count

%

P-Value

 positive regulation of transcription from RNA polymerase II promoter

4.294676

19

14.29

<  0.001

 transcription from RNA polymerase II promoter

3.946596

13

9.774

<  0.001

 neuroepithelial cell differentiation

3.074302

3

2.256

<  0.001

 spinal cord development

3.033527

4

3.008

0.001

 neural tube formation

2.951191

3

2.256

0.001

 inner ear morphogenesis

2.342119

4

3.008

0.005

 regulation of protein localization

2.342119

4

3.008

0.005

 regulation of neuron differentiation

2.141452

3

2.256

0.007

 regulation of transforming growth factor beta receptor signaling pathway

2.141452

3

2.256

0.007

 protein stabilization

1.937969

5

3.759

0.012

 fungiform papilla morphogenesis

1.892035

2

1.504

0.013

 stem cell differentiation

1.887589

3

2.256

0.013

 regulation of signal transduction

1.799832

3

2.256

0.016

 negative regulation of transcription from RNA polymerase II promoter

1.756023

11

8.271

0.018

 myotome development

1.717328

2

1.504

0.019

 GO-CC Term

Enrichment Score

Count

%

P-Value

 nucleus

4.161906

55

41.35

<  0.001

 nucleoplasm

3.062718

32

24.06

<  0.001

 cytoplasm

3.032352

50

37.59

<  0.001

 membrane

2.306958

25

18.8

0.005

 microtubule plus-end

2.297019

3

2.256

0.005

 cytosol

1.228885

29

21.8

0.059

 cytoplasmic mRNA processing body

1.060323

3

2.256

0.087

 GO-MF Term

Enrichment Score

Count

%

P-Value

 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

3.752771

9

6.767

<  0.001

 protein binding

2.747245

75

56.39

0.002

 protein channel activity

2.559552

3

2.256

0.003

 transcription regulatory region sequence-specific DNA binding

2.171926

4

3.008

0.007

 sequence-specific DNA binding

2.120902

10

7.519

0.008

 RNA polymerase II core promoter proximal region sequence-specific DNA binding

2.024814

8

6.015

0.009

 chromatin binding

1.812398

8

6.015

0.015

 RNA polymerase II transcription coactivator activity

1.602367

3

2.256

0.025

 N6-methyladenosine-containing RNA binding

1.341641

2

1.504

0.046

 protein kinase activity

1.042052

6

4.511

0.091

 KEGG pathway

Enrichment Score

Count

%

P-Value

 PI3K-Akt signaling pathway

1.809894

7

5.263

0.015

 Oocyte meiosis

1.553469

4

3.008

0.028

 Platelet activation

1.379399

4

3.008

0.042

 Insulin signaling pathway

1.315081

4

3.008

0.048

 Hippo signaling pathway

1.219786

4

3.008

0.06

 Purine metabolism

1.062637

4

3.008

0.087

 ErbB signaling pathway

1.024741

3

2.256

0.094