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Table 7 The top significant changes in GO-BP (A), −CC (B), −MF(C) and KEGG pathway (D) according to differentially expressed genes in LINC00261-ceRNA sub-network

From: Reconstruction of lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveals functional lncRNAs in skin cutaneous melanoma

A
 GO-BP Term Enrichment Score Count % P-Value
 positive regulation of transcription from RNA polymerase II promoter 4.294676 19 14.29 <  0.001
 transcription from RNA polymerase II promoter 3.946596 13 9.774 <  0.001
 neuroepithelial cell differentiation 3.074302 3 2.256 <  0.001
 spinal cord development 3.033527 4 3.008 0.001
 neural tube formation 2.951191 3 2.256 0.001
 inner ear morphogenesis 2.342119 4 3.008 0.005
 regulation of protein localization 2.342119 4 3.008 0.005
 regulation of neuron differentiation 2.141452 3 2.256 0.007
 regulation of transforming growth factor beta receptor signaling pathway 2.141452 3 2.256 0.007
 protein stabilization 1.937969 5 3.759 0.012
 fungiform papilla morphogenesis 1.892035 2 1.504 0.013
 stem cell differentiation 1.887589 3 2.256 0.013
 regulation of signal transduction 1.799832 3 2.256 0.016
 negative regulation of transcription from RNA polymerase II promoter 1.756023 11 8.271 0.018
 myotome development 1.717328 2 1.504 0.019
B
 GO-CC Term Enrichment Score Count % P-Value
 nucleus 4.161906 55 41.35 <  0.001
 nucleoplasm 3.062718 32 24.06 <  0.001
 cytoplasm 3.032352 50 37.59 <  0.001
 membrane 2.306958 25 18.8 0.005
 microtubule plus-end 2.297019 3 2.256 0.005
 cytosol 1.228885 29 21.8 0.059
 cytoplasmic mRNA processing body 1.060323 3 2.256 0.087
C
 GO-MF Term Enrichment Score Count % P-Value
 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding 3.752771 9 6.767 <  0.001
 protein binding 2.747245 75 56.39 0.002
 protein channel activity 2.559552 3 2.256 0.003
 transcription regulatory region sequence-specific DNA binding 2.171926 4 3.008 0.007
 sequence-specific DNA binding 2.120902 10 7.519 0.008
 RNA polymerase II core promoter proximal region sequence-specific DNA binding 2.024814 8 6.015 0.009
 chromatin binding 1.812398 8 6.015 0.015
 RNA polymerase II transcription coactivator activity 1.602367 3 2.256 0.025
 N6-methyladenosine-containing RNA binding 1.341641 2 1.504 0.046
 protein kinase activity 1.042052 6 4.511 0.091
D
 KEGG pathway Enrichment Score Count % P-Value
 PI3K-Akt signaling pathway 1.809894 7 5.263 0.015
 Oocyte meiosis 1.553469 4 3.008 0.028
 Platelet activation 1.379399 4 3.008 0.042
 Insulin signaling pathway 1.315081 4 3.008 0.048
 Hippo signaling pathway 1.219786 4 3.008 0.06
 Purine metabolism 1.062637 4 3.008 0.087
 ErbB signaling pathway 1.024741 3 2.256 0.094