Table 1 Characteristic of 30 included studies
From: Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies
First author, Year | Country | Pathological type of thyroid cancer | Source of controls | Number of participants, n | Mean age, year | Female (%) | Outcome index | |||
|---|---|---|---|---|---|---|---|---|---|---|
cases | control | cases | control | cases | control | |||||
L. Kayser, 1996 [33] | Denmark | PTC and FTC | multinodular goiters, adenomas, Hashimoto’s thyroiditis, hyperplastic glands | 10 | 29 | Unknown | Unknown | TNF-α (+) %--tissue | ||
Cao Guangyao, 1998 [24] | China | Unknown | thyroid adenoma and nodular goiter | 44 | 27 | Unknown | Unknown | TNF-α (+) %--tissue | ||
M.Trovato, 2003 [23] | Italy | DTC and undifferentiated carcinoma | normal thyroid tissues and benign nodules | 28 | 46 | Unknown | Unknown | IL-6 (+) %--tissue | ||
Zhao Jianqiang, 2007 [25] | China | PTC, FTC, ATC and MTC | thyroid adenoma and normal health | 236 | 131 | Unknown | Unknown | IL-6、TNF-α--blood | ||
Melih Akinci, 2009 [41] | Turkey | PTC | healthy volunteers | 43 | 30 | 42.8 ± 13.2 | 54.6 ± 8.9 | 100% | 100% | leptin--blood |
Wang Jingxia, 2009 [26] | China | PTC and FTC | normal thyroid tissues | 62 | 18 | Unknown | 87.10% | Unknown | TNF-α (+) %--tissue | |
Zhuang Xiaoming, 2010 [27] | China | PTC, FTC and MTC | thyroid adenoma and normal health | 38 | 100 | 46 | 46/48 | 73.70% | Unknown | IL-6、TNF-α--blood |
Yu Xiao, 2011 [28] | China | PTC | thyroid adenoma and normal thyroid tissue near carcinoma | 58 | 26 | Unknown | Unknown | leptin(+)%--tissue | ||
Hou Sen, 2013 [29] | China | PTC | thyroid adenoma | 76 | 16 | Unknown | 73.70% | Unknown | leptin(+)%--tissue | |
Snezana Zivancevic-Simonovic, 2014 [42] | Serbia | WDTC | healthy subjects | 13 | 13 | 51.23 ± 14.9 | 45.75 ± 12.89 | 84.60% | 84.60% | TNF-α--blood |
Xu Xiaocheng, 2014 [30] | China | thyroid carcinoma | thyroid adenoma | 44 | 36 | 54.3 ± 18.6 | 58.4 ± 17.4 | 36.40% | 55.60% | IL-6--blood |
Xeni Provatopoulou, 2014 [43] | Greece | PTC | benign thyroid disease and healthy controls | 20 | 38 + 50 | 49.2 ± 13.7 | 48.9 ± 14.5 / 49.5 ± 13.2 | 80% | 81.6% / 86.0% | IL-6--blood |
Sun Qinnuan, 2014 [31] | China | PTC | normal thyroid tissue near carcinoma and healthy controls | 74 | 74 + 26 | 40.3 ± 3.6 | 40.3 ± 3.6 / 37.9 ± 2.4 | 60.81% | 60.81% / 53.85% | TNF-α--blood and tissue |
Zhang Zijie, 2014 [32] | China | PTC | thyroid adenoma | 60 | 20 | Unknown | 73.33% | Unknown | leptin(+)%--tissue | |
Zhong Xiuxiu, 2014 [33] | China | PTC | thyroid adenoma | 78 | 12 | Unknown | Unknown | adiponectin(+)% --tissue | ||
Zhang Bo, 2014 [34] | China | DTC | normal thyroid tissue near carcinoma | 167 | 40 | Unknown | 82.63% | Unknown | adiponectin--tissue | |
Hu Jinhua, 2015 [35] | China | DTC | thyroid adenoma and healthy controls | 64 | 42 + 40 | 49.8 ± 9.1 | 36.8 ± 11.3 / 45.3 ± 8.1 | 75% | 69.04% / 70% | IL-6、 TNF-α--blood |
Snezana Zivancevic-Simonovic, 2015 [44] | Serbia | PTC | control subjects | 16 | 24 | Unknown | Unknown | IL-6--blood | ||
Yan-Lan Fan, 2015 [45] | China | thyroid carcinoma | nodular goitre, Hashimoto’s thyroiditis, follicular adenoma and adjacent non-neoplastic thyroid tissue samples | 173 | 162 | Unknown | Unknown | leptin(+)%--tissue | ||
Wang Xinzheng, 2015 [36] | China | thyroid carcinoma | benign thyroid disease and normal thyroid tissue near benign thyroid disease | 40 | 40 + 40 | 72.35 ± 7.44 | 72.83 ± 7.73 | 40% | 35% / 35% | TNF-α--tissue |
Song Runbo, 2015 [37] | China | PTC | thyroid adenoma | 60 | 60 | 40.5 ± 8.4 | 46.7 ± 5.6 | 60% | 53.33% | TNF-α (+) %--tissue |
Kemal Beksac, 2016 [46] | Turkey | PTC | healthy volunteers | 31 | 39 | 44 | 41 | 100% | 100% | IL-6--blood |
Toral P. Kobawala, 2016–1 [47] | India | PTC | benign thyroid diseases and healthy individuals | 83 | 67 + 67 | Unknown | 67.47% | Unknown | TNF-α--blood | |
Toral P. Kobawala, 2016–2 [48] | India | PTC | benign thyroid diseases and healthy individuals | 84 | 67 + 67 | Unknown | 67.47% | Unknown | IL-6--blood | |
Raziyeh Abooshahab, 2016 [20] | Iran | MTC | healthy subjects | 45 | 45 | 29.46 ± 13.97 | 27.53 ± 13.66 | 53.33% | 46.67% | leptin、 adiponectin--blood |
Zhang Bo, 2016 [38] | China | DTC | normal thyroid tissue near carcinoma | 167 | 40 | Unknown | 82.63% | Unknown | leptin--tissue | |
Zhou Xiaodong, 2016 [39] | China | DTC | healthy subjects | 50 | 50 | 43.82 ± 12.58 | 42.96 ± 13.29 | 56% | 52% | IL-6、TNF-α--blood |
Ma Xiaokai, 2016 [22] | China | PTC | thyroid adenoma | 60 | 45 | Unknown | 58.33% | Unknown | leptin(+)%--tissue | |
Mariana Bonjiorno Martins, 2017 [49] | Brazil | DTC | benign thyroid nodules and healthy controls | 200 | 60 + 100 | 40.73 ± 13.88 | 47.95 ± 14.17 / 40.35 ± 13.34 | 86.50% | 91.67% / 82% | IL-6--blood |
Sun Zhenhua, 2017 [21] | China | PTC | nodular goiter | 50 | 20 | 41.2 | 43.1 | 64% | 70% | IL-6 (+) %--tissue |