Post-diagnosis dietary insulinemic potential and survival outcomes among colorectal cancer patients

BMC Cancer

Table 3 Hazard ratios (95% CI) for colorectal cancer-specific and all-cause mortality among patients with colorectal cancer by quintile of post-diagnosis EDIH score

	Quintiles of the empirical dietary index for hyperinsulinemia (EDIH) score					P-trend
Statistical model	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5	P-trend
Colorectal cancer-specific mortality
Deaths/Patients alive	43/300	60/284	56/288	57/287	56/287
Minimally-adjusted model	1 (reference)	1.39 (0.94, 20.6)	1.27 (0.85, 1.90)	1.41 (0.94, 2.11)	1.62 (1.08, 2.42)	0.03
Fully adjusted model	1 (reference)	1.44 (0.96, 2.18)	1.33 (0.87, 2.02)	1.45 (0.94, 2.26)	1.66 (1.03, 2.69)	0.07
All-cause mortality
Deaths/Patients alive	178/165	204/140	204/140	215/129	207/136
Minimally-adjusted model	1 (reference)	1.22 (1.00, 1.49)	1.21 (0.99, 1.48)	1.46 (1.19, 1.78)	1.35 (1.10, 1.65)	0.002
Fully adjusted model	1 (reference)	1.23 (1.00, 1.52)	1.20 (0.97, 1.49)	1.39 (1.11, 1.73)	1.24 (0.97, 1.58)	0.08

The minimally-adjusted models was adjusted for age at diagnosis, post-diagnosis body mass index, total energy intake, sex, race, year of diagnosis, cancer stage, grade of tumor differentiation, and location of primary tumor within the colon; the fully-adjusted model was additionally adjusted for post-diagnosis physical activity, post-diagnosis pack years of smoking, post-diagnosis regular aspirin use, weight change pre to post-diagnosis, post-diagnosis total alcohol intake, and pre-diagnosis EDIH score

ISSN: 1471-2407