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Fig. 2 | BMC Cancer

Fig. 2

From: An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types

Fig. 2

Prognostic significance of AMPK loss- and gain-of-function genes. a Heatmap illustrates significant hazard ratio values from Cox proportional hazards regression analyses on the 24 loss-of-function and seven gain-of-function genes across all cancers. b The distributions of 24-AMPK-gene scores in each cancer are illustrated in the boxplot. Cancers are sorted from low to high median scores. Refer to Fig. 1 legend for cancer abbreviations. c Kaplan-Meier analyses and log-rank tests revealed the prognostic significance of the 24-AMPK-gene set in four cancer types. Patients are stratified into Q1 (1st quartile) and Q4 (4th quartile) groups based on their 24-gene scores for log-rank tests. d Multidimensional scaling analyses of the 24-gene set depicted in 2-dimensional space. Significance differences in the distribution between tumor and non-tumor samples are confirmed by PERMANOVA

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