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Table 1 Genes that negatively correlate with SOCS1 and/or SOCS3 and their impact on patient survival. * High expression predicts better survival, for all others poor survival

From: Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma

SOCS Negatively correlated genes Oncogenic signaling Pathway Upregulation in tumor vs normal
p value
Survival
Probability
p value
SOCS1 No difference 0.013
SOCS1 CDK2 Cell cycle regulation 0.0001 0.011
PIK3R1* PI3K-AKT-MTOR No difference (0.012)*
SOCS3 E2F8 Cell cycle regulation 0.0001 0.006
AKT1S1 PI3K-AKT-MTOR 0.0001 0.00073
MLST8 PI3K-AKT-MTOR 0.0001 0.0014
AURKA Other Growth signaling 0.0001 0.0016
MAP 3 K4 RAS-RAF-MEK-MAPK 0.0001 0.0025
SOCS1,
SOCS3
RPTOR PI3K-AKT-MTOR 0.0001 0.0043
BRAF RAS-RAF-MEK-MAPK 0.0001 0.0066
MAPK1 RAS-RAF-MEK-MAPK 0.0001 0.013
  1. *High expression predicts better survival, for all others poor survival