Table 1 Genes that negatively correlate with SOCS1 and/or SOCS3 and their impact on patient survival. * High expression predicts better survival, for all others poor survival
SOCS | Negatively correlated genes | Oncogenic signaling Pathway | Upregulation in tumor vs normal p value | Survival Probability p value |
|---|---|---|---|---|
SOCS1 | – | – | No difference | 0.013 |
SOCS1 | CDK2 | Cell cycle regulation | 0.0001 | 0.011 |
PIK3R1* | PI3K-AKT-MTOR | No difference | (0.012)* | |
SOCS3 | E2F8 | Cell cycle regulation | 0.0001 | 0.006 |
AKT1S1 | PI3K-AKT-MTOR | 0.0001 | 0.00073 | |
MLST8 | PI3K-AKT-MTOR | 0.0001 | 0.0014 | |
AURKA | Other Growth signaling | 0.0001 | 0.0016 | |
MAP 3 K4 | RAS-RAF-MEK-MAPK | 0.0001 | 0.0025 | |
SOCS1, SOCS3 | RPTOR | PI3K-AKT-MTOR | 0.0001 | 0.0043 |
BRAF | RAS-RAF-MEK-MAPK | 0.0001 | 0.0066 | |
MAPK1 | RAS-RAF-MEK-MAPK | 0.0001 | 0.013 |