Fig. 8

Validation of genes that negatively correlate with SOCS1 or SOCS3 in murine models. a Partial hepatectomy was carried out on 8–10 weeks old mice lacking Socs1 or Socs3 in hepatocytes and control mice. The expression of the indicated genes in the regenerating livers was evaluated 24 h later by qRT-PCR. n = 4–6 mice per group. b Mice lacking Socs1 or Socs3 in hepatocytes and control mice were treated with DEN (25 mg/kg body weight) at 2 weeks of age and livers collected at 8–10 months of age. Tumor nodules and adjacent normal liver tissues were resected and expression of the indicated genes was evaluated by qRT-PCR. n = 4–6 mice per group. p-values were calculated by one-way ANOVA along with Tukey’s Multiple Comparison test: * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001