Fig. 4

A 56-year-old woman with CRCLM, a, a coronal contrast-weighted image and b, an Axial T2-weighted image showed that the doubtful neoplasm near the rectum infiltrates the surrounding fat space. The doubtful neoplasm could be distinguished in T1-weighted and contrast-weighted images were shown in c, and f, h. And the DWI and IVIM-DWI images were shown and measured in d, g and k. Subsequently, liver biopsy for the doubtful neoplasm was performed and a small number of histological biopsy samples confirmed liver tumor as rectal adenocarcinoma liver metastasis. MRI imaging PDFF maps and NC-induced histopathological changes in a patient, 48-year-old man, who was diagnosed as CRCLM and underwent 6 courses of NC before liver metastatic tumor resection. l, the baseline map of fat fraction before NC, m, the FF map after 2 courses of NC, n, the FF map before liver resection within 3 days. H&E staining sections of liver metastatic tumor and hepatic parenchyma extra tumor in liver. o, Chemotherapeutic reactivity is characterized by a large amount of clastic necrosis in the liver tissue outside the tumor, with lymphocyte and plasma cell infiltration, p, Small bile duct hyperplasia with or without mild dilation is seen in the portal area, q, Tumor degenerative necrosis caused by chemotherapeutic reaction, with fibrous tissue hyperplasia and hyaline degeneration, collagen accumulation and inflammatory cell infiltration, r, Slight dilatation and congestion in the hepatic sinus around the portal area, steatohepatitis and large lipid droplets are deposited