Table 3 Correlations between S1PR1 and related genes and markers of immune cells, as evaluated using TIMER

Description

Gene markers

varX

cor

cor

cor

CD8+ T cell

CD8A

0.267

1.26E-17

***

0.166

2.19E-04

**

0.411

6.51E-21

***

CD8B

0.176

2.42E-08

***

0.108

1.66E-02

0.378

1.22E-17

***

T cell (general)

CD3D

0.217

4.71E-12

***

0.112

1.28E-02

0.411

7.60E-21

***

CD3E

0.276

7.15E-19

***

0.226

8.85E-07

***

0.459

2.82E-26

***

CD2

0.202

3.20E-10

***

0.159

4.00E-04

**

0.438

7.99E-24

***

B cell

CD19

0.156

7.38E-07

***

0.181

5.37E-05

***

0.324

3.78E-13

***

CD79A

0.177

1.98E-08

***

0.172

1.21E-04

**

0.325

3.29E-13

***

Monocyte

CD86

0.044

1.28E-01

0.228

2.97E-07

***

0.588

1.27E-45

***

CD115 (CSF1R)

0.202

1.29E-10

***

0.264

3.10E-08

***

0.64

2.67E-56

***

TAM

CCL2

0.111

4.68E-04

**

0.093

3.86E-02

0.44

5.89E-24

***

CD68

0.023

4.63E-01

0.289

5.86E-11

***

0.494

1.18E-30

***

IL10

0.055

8.35E-02

0.27

1.10E-09

***

0.534

1.49E-36

***

M1 Macrophage

INOS (NOS2)

0.257

1.76E-16

***

0.374

7.93E-18

***

0.079

8.64E-02

IRF5

0.016

6.18E-01

−0.042

3.55E-01

−0.036

4.31E-01

COX2 (PTGS2)

0.338

4.90E-28

***

0.095

3.58E-02

0.214

2.37E-06

***

M2 Macrophage

CD163

0.056

7.72E-02

0.331

4.36E-14

***

0.645

1.52E-57

***

VSIG4

0.08

1.14E-02

0.271

9.75E-10

***

0.625

4.77E-53

***

MS4A4A

0.23

1.96E-13

***

0.365

5.39E-17

***

0.628

9.28E-54

***

Neutrophils

CD66b (CEACAM8)

0.04

2.03E-01

0.25

1.95E-08

***

0.212

2.99E-06

***

CD11b (ITGAM)

0.007

8.24E-01

0.199

8.16E-06

***

0.491

2.66E-30

***

CCR7

0.316

1.55E-24

***

0.321

2.57E-13

***

0.514

1.70E-33

***

Natural killer cell

KIR2DL1

0.011

7.27E-01

0.216

1.30E-06

***

0.146

1.36E-03

*

KIR2DL3

0.051

1.10E-01

0.148

9.96E-04

**

0.233

2.63E-07

***

KIR2DL4

−0.027

3.95E-01

−0.03

5.06E-01

0.152

8.45E-04

**

KIR3DL1

0.095

2.63E-03

*

0.174

1.04E-04

**

0.295

4.85E-11

***

KIR3DL2

0.068

3.19E-02

0.077

8.79E-02

0.217

1.68E-06

***

KIR3DL3

−0.005

8.75E-01

0.025

5.81E-01

0.044

3.43E-01

KIR2DS4

0.035

2.68E-01

0.119

8.34E-03

*

0.221

1.05E-06

***

Dendritic cell

HLA-DPB1

0.237

3.89E-14

***

0.261

4.13E-09

***

0.621

3.86E-52

**

HLA-DQB1

0.073

2.11E-02

0.089

4.79E-02

0.4

8.84E-20

***

HLA-DRA

0.156

7.17E-07

***

0.219

8.69E-07

***

0.603

1.29E-48

**

HLA-DPA1

0.21

2.26E-11

***

0.225

4.53E-07

***

0.622

1.87E-52

**

BDCA-1(CD1C)

0.461

1.76E-53

***

0.271

1.00E-09

***

0.438

8.69E-24

***

BDCA-4(NRP1)

0.484

1.58E-59

***

0.174

1.07E-04

**

0.473

6.69E-28

***

CD11c (ITGAX)

0.087

6.21E-03

*

0.135

2.69E-03

***

0.445

1.58E-24

***

Th1

T-bet (TBX21)

0.227

4.72E-13

***

0.182

4.81E-05

***

0.403

5.17E-20

***

STAT4

0.277

5.92E-19

***

0.131

3.66E-03

***

0.504

4.73E-32

***

STAT1

0.116

2.61E-04

**

−0.046

3.10E-01

0.177

1.03E-04

**

IFN-g (IFNG)

0.009

7.84E-01

***

−0.076

9.13E-02

0.108

1.85E-02

TNF-a (TNF)

0.193

8.08E+ 10

***

−0.076

9.30E-02

0.069

1.34E-01

Th2

GATA3

0.078

1.43E-02

0.047

3.01E-01

0.232

3.00E-07

***

STAT6

0.225

6.69E-13

***

0.138

2.20E-03

*

0.022

6.25E-01

STAT5A

0.165

1.81E-07

***

0.248

2.27E-08

***

0.413

4.22E-21

***

IL13

0.048

1.27E-01

0.071

1.15E-01

0.199

1.20E-05

***

Tfh

BCL6

0.174

3.52E-08

***

0.119

8.01E-03

*

0.004

9.24E-01

IL21

0.001

9.77E-01

0.054

2.34E-01

0.207

4.92E-06

***

Th17

STAT3

0.043

1.75E-01

0.188

2.65E-05

***

0.158

6.09E-04

**

IL17A

−0.053

9.29E-02

0.033

4.62E-01

−0.038

4.09E-01

Treg

FOXP3

0.027

3.94E-01

0.058

1.98E-01

0.393

4.15E-19

***

CCR8

0.014

6.71E-01

0.157

4.61E-04

**

0.464

7.27E-27

***

STAT5B

0.283

8.58E-20

***

0.505

4.67E-12

***

0.138

2.47E-03

*

TGFb (TGFB1)

0.321

3.21E-25

***

0.198

9.43E-06

***

0.064

1.64E-01

T cell exhaustion

PD-1 (PDCD1)

0.112

4.12E-04

**

0.051

2.56E-01

0.361

3.80E-16

***

CTLA4

0.018

5.75E-01

0.081

7.27E-02

***

0.404

3.88E-20

***

LAG3

−0.109

6.00E-04

**

−0.035

4.39E-01

0.212

3.11E-06

***

TIM-3 (HAVCR2)

0.039

2.19E-01

0.213

1.78E-06

***

0.589

8.44E-46

***

GZMB

0.056

7.82E-02

0.024

5.99E-01

0.267

3.33E-09

***