Table 4 Treatment modalities and outcome of patients with PD at 9–12 months after initial therapy and at last follow-up visit according to tumor burden
9–12 months after initial therapy | At last follow-up visit | |||||||
|---|---|---|---|---|---|---|---|---|
Very small-volume PD (n = 24) | Small-volume PD (n = 25) | Large-volume PD (n = 58) | p | Very small-volume PD (n = 24) | Small-volume PD (n = 25) | Large-volume PD (n = 58) | p | |
Treatment modalitiesa | ||||||||
RAI | 24 (100%) | 25 (100%) | 58 (100%) | 10 (40%) | 4 (16%) | 19 (33%) | ||
Neck surgery | 0 | 2 (8%) | 22 (39%) | 0 | 5 (20%) | 17 (30%) | ||
Neck external radiation beam therapy | 0 | 0 | 7 (12%) | 0 | 1 (4%) | 6 (11%) | ||
Local treatment of DMb | 0 | 0 | 7 (12%) | 0 | 2 (8%) | 13 (23%) | ||
Tyrosine-kinase inhibitors | 0 | 0 | 0 | 0 | 1 (4%) | 12 (21%) | ||
Chemotherapy | 0 | 0 | 0 | 0 | 0 | 1 (2%) | ||
Outcome | < 0.0001 | 0.0003 | ||||||
Excellent response | 17 (71%) | 5 (20%) | 4 (7%) | 18 (75%) | 7(28%) | 9 (16%) | ||
Indeterminate response | 2 (8%) | 6 (24%) | 3 (5%) | 2 (8%) | 6 (24%) | 10 (17%) | ||
Biochemical incomplete response | 2 (8%) | 3 (12%) | 3 (5%) | 3 (13%) | 4 (16%) | 10 (17%) | ||
Structural incomplete response | 3 (13%) | 11 (44%) | 48 (83%) | 1 (4%) | 8 (32%) | 29 (50%) | ||