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Table 4 Multivariate analysis of prognostic factors for overall survival (OS) and disease-free survival (DFS) in matched cohort

From: Influence of tumor location on short- and long-term outcomes after laparoscopic surgery for rectal cancer: a propensity score matched cohort study

Variables OS DFS
HR 95% CI P value HR 95% CI P value
Age(y)    <0.001    0.172
 ≤ 60 1    1   
 >60 4.236 1.915–9.368   1.606 0.813–3.170  
ASA      0.071
 I     1   
 II- III     1.952 0.943–4.040  
Location    0.099    0.012
 Mid/high 1    1   
 Low 1.801 0.894–3.629   2.305 1.203–4.417  
Preoperative CEA (ng/ml)    0.908   
 ≤ 5 1      
 >5 0.954 0.431–2.110     
Preoperative CA19–9 (U/ml)    0.901    0.046
 ≤ 37 1    1   
 >37 1.061 0.420–2.680   2.362 1.014–5.505  
Pathological T stage    0.340   
 pT0–2 1      
 pT3–4 1.579 0.618–4.035     
Pathological N stage    0.001    0.010
 pN0 1    1   
 pN1–2 5.006 1.874–13.368   2.438 1.239–4.797  
Lymphovascular invasion    0.007   
 Negative 1      
 Positive 3.086 1.368–6.960     
Harvested lymph nodes      0.093
 ≥ 12     1   
 <12     1.955 0.895–4.270  
CRM (mm)      <0.001
 >1     1   
  ≤ 1     8.609 2.826–26.228  
Operative complications    0.573   
 No 1      
 Yes 1.267 0.556–2.890     
Neoadjuvant therapy      0.476
 No     1   
 Yes     1.333 0.605–2.937  
  1. - Variable not included in multivariate analysis
  2. ASA American Society of Anesthesiologists, CEA Carcinoembryonic antigen, CRM Circumferential resection margin, HR Hazard ratio, CI Confidence interval