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Table 4 Toxicity grading of different treatments after BMs, n (%)

From: Prognostic analysis of patients with non-small cell lung cancer harboring exon 19 or 21 mutation in the epidermal growth factor gene and brain metastases

 

Chemotherapy

Radiotherapy

Targeted therapy

Targeted combined radiotherapy

Grade 1

Grade 2

Grade 3

Grade 1

Grade 2

Grade 3

Grade 1

Grade 2

Grade 3

Grade 1

Grade 2

Grade 3

Weakness

10

66.7

5

33.3

0

0.0

12

44.4

4

14.8

0

0.0

0

0.0

0

0.0

0

0.0

20

51.3

5

12.8

0

0.0

Weight loss

8

53.3

2

13.3

0

0.0

5

18.5

0

0.0

0

0.0

0

0.0

0

0.0

0

0.0

8

20.5

0

0.0

0

0.0

Rash

0

0.0

0

0.0

0

0.0

0

0.0

0

0.0

0

0.0

7

50.0

3

21.4

0

0.0

16

41.0

3

7.7

0

0.0

Nausea

8

53.3

2

13.3

0

0.0

10

27.0

0

0.0

0

0.0

4

28.6

0

0.0

0

0.0

10

25.6

1

2.6

0

0.0

Vomiting

5

33.3

2

13.3

0

0.0

1

3.7

0

0.0

0

0.0

0

0.0

0

0.0v

0

0.0

2

5.1

0

0.0

0

0.0

Diarrhea

4

26.7

0

0.0

0

0.0

0

0.0

0

0.0

0

0.0

4

28.6

0

0.0

0

0.0

8

20.5

0

0.0

0

0.0v

Decreased absolute neutrophils value

5

33.3

1

6.7

1

6.7

5

18.5

1

3.7

0

0.0

0

0.0

0

0.0

0

0.0

6

15.4

2

5.1

0

0.0

Elevated ALT/AST

1

6.7

1

6.7

0

0.0

0

0.0

0

0.0

0

0.0

3

21.4

1

7.1

0

0.0

7

17.9

2

5.1

0

0.0

Elevated bilirubin

1

6.7

0

0.0

0

0.0

0

0.0

0

0.0

0

0.0

5

35.7

0

0.0

0

0.0

4

10.3

0

0.0

0

0.0

Headache

0

0.0

0

0.0

0

0.0

9

33.3

1

3.7

0

0.0

0

0.0

0

0.0

0

0.0

12

30.8

4

10.3

0

0.0

Dizziness

0

0.0

0

0.0

0

0.0

8

29.6

0

0.0

0

0.0

0

0.0

0

0.0

0

0.0

10

25.6

0

0.0

0

0.0