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Table 2 Comparisons of quality of life and symptoms between patients and controls: Results from questionnaires

From: Impact on quality of life 3 years after diagnosis of prostate cancer patients below 75 at diagnosis: an observational case-control study

Score Patients
N = 376
Controls
N = 188
p-value
QLQ-C30
 QLQ-C30 Global score, median [Q1;Q3] 94.87 [87.44; 98.72]
11 DM
94.15 [89.66; 98.21]
4 DM
0.71
 Global health status/QoL:
Worse global health (<=83.3), n(%)
117 (31.3)
2 DM
49 (26.5)
3 DM
0.25
 Physical Functioning: score < 100, n (%) 136 (36.5)
3 DM
63 (34.1)
3 DM
0.58
 Role Functioning: score < 100, n (%) 71 (19)
3 DM
25 (13.5)
3 DM
0.11
 Emotional Functioning: score < 100, n(%) 204 (54.6)
2 DM
89 (48.1)
3 DM
0.15
 Cognitive Functioning: score < 100, n(%) 170 (45.6)
3 DM
99 (53.5)
3 DM
0.0799†
 Social Functioning: score < 100, n (%) 91 (24.3)
2 DM
30 (16.3)
4 DM
0.0332*
 Fatigue: score > 0, n (%) 167 (44.7)
2 DM
84 (45.4)
3 DM
0.87
 Nausea/Vomiting: score > 0, n (%) 16 (4.3)
2 DM
6 (3.2)
3 DM
0.56
 Pain: score > 0, n (%) 86 (23)
2 DM
61 (33)
3 DM
0.0131*
 Dyspnea: score > 0, n(%) 82 (22)
4 DM
23 (12.4)
3 DM
0.0078*
 Insomnia: score > 0, n (%) 128 (34.2)
2 DM
70 (37.8)
3 DM
0.40
 Appetite loss: score > 0, n (%) 19 (5.1)
4 DM
11 (6)
3 DM
0.68
 Constipation: score > 0, n (%) 69 (18.5)
3 DM
44 (23.8)
3 DM
0.15
 Diarrhea: score > 0, n (%) 53 (14.3)
5 DM
24 (13)
3 DM
0.67
 Financial Problems: score > 0, n (%) 22 (6)
10 DM
6 (3.3)
5 DM
0.18
IPSS
 Mild 254 (72.4) 141 (78.8) 0.107
 Moderate 77 (21.9) 31 (17.3)
 Severe 20 (5.7)
25 DM
7 (3.9)
9 DM
IIEF-6
 Severe erectile dysfunction 209 (65.5) 55 (32) <  0.0001
 Moderate dysfunction 28 (8.8) 19 (11.2)
 Mild to moderate dysfunction 26 (8.2) 13 (7.6)
 Mild dysfunction 20 (6.3) 26 (15.1)
 No dysfunction 36 (11.3)
57 DM
59 (34.3)
16 DM
ICIQ-MLUTS
 Voiding score (VS) 2 [0; 5]
17 DM
2 [1; 5]
6 DM
0.78
 Incontinence score (IS) 3 [1; 6]
16 DM
2 [0; 3]
5 DM
< 0.0001
 Frequency of diurnal urination    0.0884
- 1–6 times per day 213 (58.4) 124 (66.3)
- 7–8 times per day 107 (29.3) 43 (23)
- ≥9 times per day 45 (12.3)
11 DM
20 (10.7)
1 DM
 Frequency of nocturnal urination    0.99
- Never 74 (20.1) 33 (17.9)
- 1 time per night 191 (51.9) 93 (50.5)
- ≥ 2 times per night 103 (28)
8 DM
58 (31.5)
4DM
HADS Anxiety
 Absence of anxiety 266 (74.9) 140 (77.4) 0.64
 Suspected anxiety 59 (16.6) 31 (17.1)
 Probable anxiety 30 (8.5)
21 DM
10 (5.5)
7 DM
HADS Depression
 Absence of depression 303 (85.1) 155 (87.6) 0.44
 Suspected depression 36 (10.1) 15 (8.5)
 Probable depression 17 (4.8)
20 DM
7 (4)
11 DM
HADS Total score
 Absence of anxio-depressive troubles 277 (80.8) 149 (85.6) 0.17
 Presence of anxio-depressive troubles 66 (19.2)
33 DM
25 (14.4)
14 DM
  1. Data presented as number (%) or median [IQR] as appropriate. Results presented as number (%) patients in each group with functional scores < 100 and symptom scores as > 0. DM: Data missing; *significant difference (< 5%); †potentially significant difference (5–10%)