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Table 2 Sites of AEs by Grade Following Cycle of Treatment

From: Immunotherapy and associated immune-related adverse events at a large UK centre: a mixed methods study

  Cycles 1 2 3 4 5 6 7 8 9 10 11 12 13 > 13
Gastrointestinal
 Diarrhoea Mild (8) id1(9)
id51(17)
  id18(9)
id7(32)
id10(20)   id1 (9)
id33(9)
   id2(24)      
Moderate (5)      id55(6) id 36(6)    id4(9)     id60(16) id60(16)
Severe (3)    id48(3) id25(4)    id1 (9)        
 Nausea and Vomiting Mild (1)     id10(20)           
Moderate (0)               
Severe (1) id49(1)              
 Mucositis Mild (2)      id10(20)   id35(7)        
Moderate (0)               
Severe (0)               
Skin
 Itching Mild (5)    id3(6)
id24(10)
id51(17)      id13(23) id2(24)     
Moderate (2)        id8(19)    id8(19)     
Severe (0)               
 Rash Mild (2) id6(7)        id10(20)       
Moderate (0)               
Severe (0)               
Cardiovascular
 Chest pain and discomfort Mild (0)               
Moderate (1)      id1(9)          
Severe (0)               
Eye
 Visual disturbances Mild (1) id2(24)              
Moderate (0)               
Severe (0)               
 Conjunctival haemorrhage Mild (1) id5(11)              
Moderate (0)               
Severe (0)               
General
 Fatigue Mild (6)    id2(24) id3(6)
id54(5)
id7(32)
  id10(20)         id2(24)  
Moderate (3) id56(6) id12(6)         id13(23)     
Severe (0)               
 Dizziness Mild (0)               
Moderate (1) id16(3)              
Severe (0)               
 Nail Changes Mild (1)    id37(5)            
Moderate (0)               
Severe (0)               
 Other Mild (1)    id54(5)            
Moderate (0)               
Severe (1) id58(1)              
 Fever Mild (2) id54(5) id59(2)             
Moderate (1) id27(1)              
Severe (2)     id4(9)
id25(4)
          
Endocrine
 Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Mild (0)               
Moderate (1) id56(6)              
Severe (0)               
 Hypothyroidism Mild (1)              id2(24)  
Moderate (5)     id13(23)
id51(17)
   id7(32)   id14(19)
id7(32)
     
Severe (0)               
 Raised blood glucose Mild (1) id5(11)              
Moderate (0)               
Severe (0)               
Respiratory
 Cough Mild (1) id32(1)              
Moderate (0)               
Severe (0)               
 Shortness of Breath Mild (4) id6(7)   id2(24)            id2(24)
Moderate (4)   id9(17)   id55(6)    id7(32)       id2(24)  
Severe (2) id15(1)
id 36(6)
             
Renal
 Renal function Mild (1) id6(7)              
Moderate (0)               
Severe (0)               
Rheumatological
 Joint Pain Mild (3) id17(2)   id56(6)      id51(17)       
Moderate (1) id9(17)              
Severe (2) id11(17)
id18(9)
             
Musculoskeletal
Bone Pain Mild (0)               
Moderate (2) id34(3)         id51(17)      
Severe (0)               
Hepatic
 Liver function tests deranged Mild (0)               
Moderate (1)              id60(16)  
Severe (0)               
  TOTAL
Mild (40)
Moderate (27)
Severe (11)
n = 78
              
  1. NB Following patient id bracket = number of cycles received