Clinical parameter | N, studies | N, patients | Overall OR | 95% CI | I2 (%) | Significance (P) | Egger P |
---|---|---|---|---|---|---|---|
Age ≥ 65 years vs < 65 years | 2 | 593 | 0.818 | 0.490–1.364 | 0 | 0.441 | NA |
Male vs female | 5 | 783 | 0.812 | 0.556–1.185 | 4.3 | 0.280 | 0.743 |
Ever smoker vs nerver smoker | 5 | 774 | 0.955 | 0.641–1.423 | 0.5 | 0.823 | 0.106 |
ECOG > 1 vs ≤ 1 | 4 | 965 | 1.524 | 1.009–2.301 | 0 | 0.045 | 0.471 |
RMH ≥ 2 vs < 2 | 2 | 332 | 4.556 | 2.424–8.561 | 0 | < 0.001 | NA |
Neutrophil-to-lymphocyte ratio ≤ 3 vs > 3 | 3 | 680 | 0.595 | 0.265–1.334 | 73.5 | 0.208 | 0.747 |
Serum lactate dehydrogenase > upper normal limit | 3 | 493 | 2.285 | 1.360–3.839 | 24.2 | 0.002 | 0.606 |
No. of metastasis > 2 vs ≤ 2 | 5 | 1054 | 2.231 | 1.321–3.767 | 50 | 0.003 | 0.339 |
Liver metastasis | 3 | 602 | 3.173 | 1.920–5.244 | 0 | < 0.001 | 0.109 |
PD-1 vs PD-L1 | 4 | 930 | 1.497 | 0.875–2.561 | 0 | 0.141 | 0.946 |
PD-L1 positive | 5 | 546 | 0.776 | 0.499–1.205 | 0 | 0.259 | 0.460 |
Monotherapy vs combination | 2 | 557 | 0.511 | 0.033–7.898 | 83.3 | 0.631 | NA |
Previous treatment lines > 2 | 4 | 856 | 0.741 | 0.394–1.393 | 70.5 | 0.352 | 0.923 |
Squamous | 5 | 1143 | 0.832 | 0.587–1.179 | 0 | 0.301 | 0.828 |
EGFR mutation | 5 | 928 | 0.956 | 0.537–1.705 | 0 | 0.880 | 0.148 |
KRAS mutation | 3 | 487 | 0.992 | 0.535–1.840 | 0 | 0.980 | 0.502 |
ALK rearrangement | 3 | 660 | 2.860 | 0.652–12.547 | 0 | 0.164 | 0.151 |