Fig. 2

Schematic of the association between genetic alterations and genetic signatures. All 342 cases were clustered and arranged according to the absent/present status of four genetic signatures. We determined the prevalence of each genetic alteration in the following six subsets: 1) cases presented isolated MYC-trans signatures, 2) cases presented isolated BCL2-trans signatures, 3) cases presented isolated BCL6-trans signatures, 4) cases presented isolated MC signatures, 5) GCB cases without any genetic signatures, and 6) non-GCB cases without any genetic signatures. Genetic alterations were thus clustered into six corresponding classes depending on their maximum prevalence among the six subsets. Genetic alterations in the same cluster were ranked by the significance between cases with isolated corresponding genetic signatures and cases without corresponding genetic signatures (or “other GCB”/“non-GCB” vs. the remaining), with log₁₀P value depicted to the right of the factorized heatmap. Color code of genetic alteration types: missense mutation or in-frame deletion/insertion (blue), truncating mutation, splice donor/acceptor site mutation, or copy number loss in TP53 (red), SHM (yellow), translocation (orange), and nondetected (gray). COO classification was also indicated above the factorized heatmap