Skip to main content

Table 2 Association of stage IV disease with various factors in men and women

From: Gender differences in stage at diagnosis and preoperative radiotherapy in patients with rectal cancer

  Stage IV
Men Women p-value for gender interaction3
N n (%) P1 N n (%) P1  
Age    0.382    0.202 0.80
  < 65 years 221 17 (7.7)   108 14 (13.0)   
 65–80 years 245 14 (5.7)   105 10 (9.5)   
  > 80 years 56 3 (5.4)   35 2 (5.7)   
Charlson index    0.44    0.10 0.33
 0 258 19 (7.4)   165 21 (12.7)   
  ≥ 1 264 15 (5.7)   83 5 (6.0)   
Screening    0.43    0.07 0.002
 No 429 30 (7.0)   201 17 (8.5)   
 Yes 68 2 (2.9)   30 5 (16.7)   
 Unknown 25 2 (8.0)   17 4 (23.5)   
Diagnostic delay    0.16    0.37 0.004
  ≤ 3 months 374 29 (7.8)   155 13 (8.4)   
  > 3 months 83 2 (2.4)   59 8 (13.6)   
 Unknown 65 3 (4.6)   34 5 (14.7)   
Distance from anal verge    0.34    0.83 0.67
  < 5 cm 100 3 (3.0)   57 5 (8.8)   
 5–10 cm 218 15 (6.9)   83 10 (12.0)   
  > 10 cm 167 12 (7.2)   90 10 (11.1)   
 Unknown 37 4 (10.8)   18 1 (3.8)   
Histological classification    0.49    0.04 0.25
 Adenocarcinoma 474 31 (6.5)   208 18 (8.7)   
 Mucinous adenocarcinoma 18 0 (0)   14 1 (7.1)   
 Undifferentiated carcinomas 6 1 (16.7)   4 1 (25.0)   
 Unknown 24 2 (8.3)   22 6 (27.3)   
Preoperative radiotherapy    0.52    0.10 0.21
 No 233 17 (7.3)   124 17 (13.7)   
 Yes 289 17 (5.9)   124 9 (7.3)   
  1. 1 Pearson’s chi-square test
  2. 2 Chi-square test for trend
  3. 3 Likelihood ratio test for gender interaction