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Table 3 Associations of MRS and Risk of CRC According to Age, Gender and Time-To-Diagnosis of Nested Case Control Study Based on EPIC-Italy Cohort

From: A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility

Characteristics Entire Dataset Training Dataset Testing Dataset
OR 95% CI P-value OR 95% CI P-value OR 95% CI P-value
Age
  < 60 2.35 1.95, 2.90 < 0.0001 2.62 2.06, 3.44 < 0.0001 1.97 1.44, 2.84 < 0.0001
  ≥ 60 2.60 1.77, 4.17 < 0.0001 2.87 1.77, 5.35 0.0002 2.28 1.20, 5.51 0.03
Gender
 Male 1.97 1.47, 2.71 < 0.0001 2.10 1.44, 3.21 0.0002 1.91 1.20, 3.37 0.02
 Female 2.64 2.12, 3.37 < 0.0001 2.96 2.26, 4.08 < 0.0001 2.08 1.46, 3.20 0.0002
Time-diagnosis
  < 6 years 2.21 1.80, 2.77 < 0.0001 2.40 1.86, 3.20 < 0.0001 1.99 1.40, 3.02 0.0004
  ≥ 6 years 2.51 2.01, 3.23 < 0.0001 2.88 2.17, 4.01 < 0.0001 1.97 1.36, 3.05 0.0008
  1. Abbreviations: CI Confidence interval, CRC Colorectal cancer, MRS Methylation risk score, OR Odds ratios adjusted for age and gender, P values < 0.05 are in bold