Table 2 Differential effects of cytokines on depression in controls and patients with breast cancer receiving/not receiving chemotherapy
Cytokines | Effect of cytokines on depression between groups | Noncancer control vs. Breast cancer group not receiving chemotherapy | Noncancer control vs. Breast cancer group receiving chemotherapy | Breast cancer group receiving chemotherapy vs. Breast cancer group not receiving chemotherapy | ||
|---|---|---|---|---|---|---|
Noncancer control | Breast cancer group not receiving chemotherapy | Breast cancer group receiving chemotherapy | ||||
Regression coefficient (standard error) | ||||||
Pro-inflammatory | ||||||
 IL-1β | − 0.60 (1.04) | −1.19 (0.82) | 1.19 (1.14) | 1.19 (1.60) | −1.25 (2.02) | 2.43 (1.56) |
 IL-2 | − 0.24 (0.43) | −1.20 (0.55)* | 0.70 (0.66) | 1.19 (0.67) | −0.44 (0.96) | 1.63 (0.89) |
 IL-6 | −0.07 (0.29) | −0.31 (0.37) | − 0.17 (0.26) | 0.20 (0.52) | − 0.02 (0.56) | 0.22 (0.46) |
 IL-12p70 | −0.005 (0.29) | −0.14 (0.39) | 0.81 (0.35)* | 0.40 (0.46) | −0.60 (0.60) | 0.99 (0.55) |
 IL-17A | −0.11 (0.17) | −0.15 (0.19) | 0.05 (0.22) | 0.19 (0.23) | −0.05 (0.33) | 0.24 (0.30) |
 IFNγ | −0.03 (0.08) | −0.07 (0.12) | 0.05 (0.14) | 0.12 (0.13) | −0.10 (0.19) | 0.22 (0.18) |
 TNFα | 0.04 (0.18) | 0.02 (0.22) | 0.05 (0.20) | −0.10 (0.31) | −0.18 (0.38) | 0.07 (0.32) |
Anti-inflammatory | ||||||
 IL-4 | −0.01 (0.06) | 0.07 (0.06) | 0.12 (0.07) | −0.02 (0.09) | −0.06 (0.13) | 0.04 (0.11) |
 IL-5 | −0.63 (0.43) | −0.97 (0.52) | 0.66 (0.53) | 0.65 (0.70) | −0.94 (0.89) | 1.59 (0.78)* |
 IL-10 | −0.14 (0.12) | −0.06 (0.14) | 0.04 (0.15) | 0.05 (0.19) | −0.03 (0.25) | 0.08 (0.23) |
 IL-13 | −0.12 (0.19) | −0.29 (0.24) | − 0.04 (0.13) | 0.26 (0.32) | − 0.05 (0.31) | 0.31 (0.24) |