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Table 4 Pool effects of Clinicopathologic characteristics in cancer patients with abnormal BANCR expression

From: High BANCR expression is associated with worse prognosis in human malignant carcinomas: an updated systematic review and meta-analysis

Clinicopathologic characteristics No. of studies No. of patients Odds ratio (95% CI) P Heterogeneity
Fixed Random I2(%) P-value
Age 15 1469 0.88 (0.71–1.09) 0.88 (0.71–1.09) 0.236 0.0 0.672
gender 13 1218 0.91 (0.72–1.16) 0.91 (0.70–1.18) 0.469 9.1 0.355
TNM (III + IV vs. I + II) 14 1378 2.27 (1.82–2.84) 2.39 (1.26–4.53) 0.008 83.9 0.000
Digestive system 7 724 3.69 (2.67–5.10) 4.01 (2.45–6.57) 0.0001 49 0.07
Respiratory system 1 113 0.26 (0.11–0.60) 0.26 (0.11–0.60) 0.002
Female reproductive system 1 30 12.25 (1.27–118.36) 12.25 (1.27–118.36) 0.03
Other system malignancy 5 511 1.89 (1.30–2.73) 1.34 (0.38–4.79) 0.65 88 0.000
LNM (present vs. absent) 12 1226 2.09 (1.65–2.64) 2.03(1.08–3.83) 0.028 82.2 0.000
Digestive system 5 600 3.35 (2.38–4.72) 3.41 (2.32–5.00) 0.00001 15 0.320
Respiratory system 1 113 0.28 (0.13–0.61) 0.28 (0.13–0.61) 0.001
Female reproductive system 1 30 9.33 (0.96–90.94) 9.33 (0.96–90.94) 0.05
Other system malignancy 5 483 1.92 (1.30–2.84) 1.30 (0.43–3.94) 0.64 82 0.000
Tumor size (big vs small) 14 1325 1.56 (1.25–1.95) 1.63(1.09–2.46) 0.020 66.0 0.000
Digestive system 6 571 1.45 (1.04–2.03) 1.45 (0.96–2.20) 0.080 29.0 0.220
Respiratory system 1 113 0.28 (0.13–0.60) 0.28 (0.13–0.60) 0.001
Other system malignancy 7 631 2.44 (1.74–3.41) 2.45 (1.74–3.45) 0.000 0.0 0.510
Histological grade 10 830 1.47(1.10–1.97) 1.54 (1.00–2.38) 0.050 44.0 0.060
Digestive system 6 646 1.28 (0.92–1.78) 1.25 (0.72–2.17) 0.440 57.0 0.040
Non-digestive system 4 174 2.45 (1.30–4.63) 2.43 (1.28–4.63) 0.007 0.0 0.660
DM (present vs. absent) 4 485 3.08 (1.92–4.96) 2.87 (1.58–5.21) 0.001 23.0 0.273
Invasion depth (T3 + T4/T1 + T2) 4 534 1.54 (1.06–2.24) 1.37(0.66–2.83) 0.02 69 0.020
smoking (smoker vs. non-smoker) 3 330 1.01 (0.65–1.56) 1.01 (0.56–1.82) 0.98 41.0 0.184
local tumors (multiple/total) 4 355 1.78 (1.12–2.83) 1.89 (0.95–3.74) 0.07 45 0.140
  1. Note: BANCR BRAF-activated noncoding RNA; LNM Lymph node metastasis; Random Random-effect model; TNM TNM stage;
  2. DM Distant metastasis; Fixed Fixed-effect model