Table 4 Pool effects of Clinicopathologic characteristics in cancer patients with abnormal BANCR expression
Clinicopathologic characteristics | No. of studies | No. of patients | Odds ratio (95% CI) | P | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
Fixed | Random | I2(%) | P-value | ||||
Age | 15 | 1469 | 0.88 (0.71–1.09) | 0.88 (0.71–1.09) | 0.236 | 0.0 | 0.672 |
gender | 13 | 1218 | 0.91 (0.72–1.16) | 0.91 (0.70–1.18) | 0.469 | 9.1 | 0.355 |
TNM (III + IV vs. I + II) | 14 | 1378 | 2.27 (1.82–2.84) | 2.39 (1.26–4.53) | 0.008 | 83.9 | 0.000 |
Digestive system | 7 | 724 | 3.69 (2.67–5.10) | 4.01 (2.45–6.57) | 0.0001 | 49 | 0.07 |
Respiratory system | 1 | 113 | 0.26 (0.11–0.60) | 0.26 (0.11–0.60) | 0.002 | – | – |
Female reproductive system | 1 | 30 | 12.25 (1.27–118.36) | 12.25 (1.27–118.36) | 0.03 | – | – |
Other system malignancy | 5 | 511 | 1.89 (1.30–2.73) | 1.34 (0.38–4.79) | 0.65 | 88 | 0.000 |
LNM (present vs. absent) | 12 | 1226 | 2.09 (1.65–2.64) | 2.03(1.08–3.83) | 0.028 | 82.2 | 0.000 |
Digestive system | 5 | 600 | 3.35 (2.38–4.72) | 3.41 (2.32–5.00) | 0.00001 | 15 | 0.320 |
Respiratory system | 1 | 113 | 0.28 (0.13–0.61) | 0.28 (0.13–0.61) | 0.001 | – | – |
Female reproductive system | 1 | 30 | 9.33 (0.96–90.94) | 9.33 (0.96–90.94) | 0.05 | – | – |
Other system malignancy | 5 | 483 | 1.92 (1.30–2.84) | 1.30 (0.43–3.94) | 0.64 | 82 | 0.000 |
Tumor size (big vs small) | 14 | 1325 | 1.56 (1.25–1.95) | 1.63(1.09–2.46) | 0.020 | 66.0 | 0.000 |
Digestive system | 6 | 571 | 1.45 (1.04–2.03) | 1.45 (0.96–2.20) | 0.080 | 29.0 | 0.220 |
Respiratory system | 1 | 113 | 0.28 (0.13–0.60) | 0.28 (0.13–0.60) | 0.001 | – | – |
Other system malignancy | 7 | 631 | 2.44 (1.74–3.41) | 2.45 (1.74–3.45) | 0.000 | 0.0 | 0.510 |
Histological grade | 10 | 830 | 1.47(1.10–1.97) | 1.54 (1.00–2.38) | 0.050 | 44.0 | 0.060 |
Digestive system | 6 | 646 | 1.28 (0.92–1.78) | 1.25 (0.72–2.17) | 0.440 | 57.0 | 0.040 |
Non-digestive system | 4 | 174 | 2.45 (1.30–4.63) | 2.43 (1.28–4.63) | 0.007 | 0.0 | 0.660 |
DM (present vs. absent) | 4 | 485 | 3.08 (1.92–4.96) | 2.87 (1.58–5.21) | 0.001 | 23.0 | 0.273 |
Invasion depth (T3 + T4/T1 + T2) | 4 | 534 | 1.54 (1.06–2.24) | 1.37(0.66–2.83) | 0.02 | 69 | 0.020 |
smoking (smoker vs. non-smoker) | 3 | 330 | 1.01 (0.65–1.56) | 1.01 (0.56–1.82) | 0.98 | 41.0 | 0.184 |
local tumors (multiple/total) | 4 | 355 | 1.78 (1.12–2.83) | 1.89 (0.95–3.74) | 0.07 | 45 | 0.140 |