Genes | NM (Our cohort) | Lung cancer (COSMIC database) | p-value |
---|---|---|---|
ABL1 | 1/45 (2.22%) | 64/5425 (1.18%) | 0.417 |
AKT1 | 1/45 (2.22%) | 63/10898 (0.58%) | 0.232 |
APC | 17/45 (37.78%) | 200/5979 (3.35%) | < 0.001 |
ATM | 3/45 (6.67%) | 288/5300 (5.43%) | 0.974 |
BAP1 | 1/45 (2.22%) | 51/4574 (1.11%) | 0.401 |
BCL9 | 1/45 (2.22%) | 0/2603 (0.00%) | 0.017 |
BRAF | 4/45 (8.89%) | 596/26989 (2.21%) | 0.033 |
BRCA1 | 2/45 (4.44%) | 122/4786 (2.55%) | 0.744 |
BRCA2 | 7/45 (15.56%) | 156/4753 (3.28%) | < 0.001 |
CBL | 5/45 (11.11%) | 69/4871 (1.42%) | 0.001 |
CDH1 | 1/45 (2.22%) | 50/5014 (1.00%) | 0.367 |
CDK4 | 1/45 (2.22%) | 11/4572 (0.24%) | 0.111 |
CDKN2A | 14/45 (31.11%) | 558/7621 (7.32%) | < 0.001 |
CSF1R | 3/45 (6.67%) | 82/4775 (1.72%) | 0.044 |
CTNNB1 | 3/45 (6.67%) | 157/6679 (2.35%) | 0.161 |
DDR2 | 2/45 (4.44%) | 139/6918 (2.01%) | 0.231 |
DNMT3A | 2/45 (4.44%) | 104/4644 (2.24%) | 0.627 |
EGFR | 39/45 (86.67%) | 26,099/98618 (26.46%) | < 0.001 |
ESR1 | 1/45 (2.22%) | 64/4425 (1.45%) | 0.484 |
FBXW7 | 1/45 (2.22%) | 131/5455 (2.4%) | 1.000 |
FGFR2 | 1/45 (2.22%) | 64/5603 (1.14%) | 0.407 |
FGFR3 | 1/45 (2.22%) | 65/6466 (1.01%) | 0.369 |
FGFR4 | 1/45 (2.22%) | 57/4569 (1.25%) | 0.436 |
FLT3 | 10/45 (22.22%) | 103/5948 (1.73%) | < 0.001 |
GNA11 | 1/45 (2.22%) | 18/4780 (0.38%) | 0.163 |
GNAQ | 14/45 (31.11%) | 24/5036 (0.48%) | < 0.001 |
HRAS | 2/45 (4.44%) | 33/7105 (0.46%) | 0.020 |
IFITM1 | 2/45 (4.44%) | 3/2468 (0.12%) | 0.003 |
JAK2 | 1/45 (2.22%) | 102/6912 (1.48%) | 0.490 |
JAK3 | 2/45 (4.44%) | 88/5176 (1.7%) | 0.181 |
KDR | 5/45 (11.11%) | 218/5112 (4.26%) | 0.060 |
KIT | 3/45 (6.67%) | 120/6695 (1.79%) | 0.048 |
KRAS | 2/45 (4.44%) | 6809/42506 (16.02%) | 0.034 |
MAP2K1 | 3/45 (6.67%) | 58/9328 (0.62%) | 0.003 |
MAP2K2 | 1/45 (2.22%) | 23/4529 (0.51%) | 0.212 |
MLH1 | 5/45 (11.11%) | 36/4969 (0.72%) | < 0.001 |
MPL | 2/45 (4.44%) | 39/4946 (0.79%) | 0.052 |
MSH2 | 3/45 (6.67%) | 54/4595 (1.18%) | 0.017 |
MYCN | 1/45 (2.22%) | 34/4544 (0.75%) | 0.293 |
NF1 | 1/45 (2.22%) | 303/4814 (6.29%) | 0.416 |
NF2 | 2/45 (4.44%) | 51/4865 (1.05%) | 0.084 |
NFE2L2 | 1/45 (2.22%) | 212/5626 (3.77%) | 0.881 |
NOTCH1 | 11/45 (24.44%) | 197/6456 (3.05%) | < 0.001 |
NRAS | 4/45 (8.89%) | 128/16010 (0.8%) | 0.001 |
PIK3CA | 2/45 (4.44%) | 719/16029 (4.49%) | 1.000 |
PTCH1 | 7/45 (15.56%) | 86/5107 (1.68%) | < 0.001 |
PTEN | 27/45 (60.00%) | 233/8576 (2.72%) | < 0.001 |
PTPN11 | 2/45 (4.44%) | 54/5910 (0.91%) | 0.066 |
RB1 | 2/45 (4.44%) | 369/5651 (6.53%) | 0.794 |
RET | 3/45 (6.67%) | 142/5818 (2.44%) | 0.181 |
SMARCB1 | 1/45 (2.22%) | 31/4968 (0.62%) | 0.251 |
SMO | 2/45 (4.44%) | 72/5105 (1.41%) | 0.136 |
STK11 | 2/45 (4.44%) | 594/8028 (7.4%) | 0.646 |
TET2 | 18/45 (40.00%) | 90/4349 (2.07%) | < 0.001 |
TP53 | 38/45 (84.44%) | 4456/11831 (37.66%) | < 0.001 |
TSC1 | 3/45 (6.67%) | 70/4775 (1.47%) | 0.030 |
TSC2 | 4/45 (8.89%) | 125/4800 (2.6%) | 0.032 |
VHL | 9/45 (20.00%) | 23/5332 (0.43%) | < 0.001 |
WT1 | 2/45 (4.44%) | 62/4634 (1.34%) | 0.125 |