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Table 1 Characteristics of 58 NM patients

From: Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing

Clinical characteristics

# of patients (%)

Gender

 Male

27 (46.6)

 Female

31 (53.4)

Age (year)

 Median (range)

55 (23–77)

Primary cancer

 Lung cancer

42 (72.4)

 Gastric cancer

4 (6.9)

 Breast cancer

3 (5.2)

 Rectal cancer

2 (3.4)

 Prostatic cancer

1 (1.7)

 Parotid carcinoma

1 (1.7)

 Lymphoma

1 (1.7)

 Glioblastoma

1 (1.7)

 Unknown malignancy

3 (5.2)

First symptom with NM

10 (17.2)

Diagnostic basis

 CSF cytology

44 (75.9)

 Neuroimaging findings

8 (13.8)

 CSF ctDNA

6 (10.3)

Treatment regimen (CSF samples)

 Intrathecal chemotherapy and systemic therapy

30 (48.4)

 Intrathecal chemotherapy without systemic therapy

11 (17.7)

 Systemic therapy without intrathecal chemotherapy

 No therapy

12 (19.4)

9 (28.5)

Hydrocephalus

 Yes

5 (8.6)

 No

53 (91.4)